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Reactive Angioendotheliomatosis – a Rare Disease Mimicking KaposiSarcoma: a Case Report


Authors: Ľ. Straka 1;  K. Adamicová 2
Authors‘ workplace: Odd. patológie FNsP J. A. Reimana, Prešov 2ÚPa MFN a UK v Bratislave JLF, Martin 1
Published in: Čes.-slov. Patol., , 2004, No. 4, p. 162-166
Category:

Overview

Reactive angioendotheliomatosis (RAE) is a rare disorder with clinical presentation of multiple cutaneous lesions. RAE mimics mainiy Kaposi sarcoma (KS) and, rarely angiosarcoma, and it usu-ally arises in association with other systemic disease. The associated disease is mostly chronic in-fection. RAE presents diagnostic problems for both the clinician and pathologist. We present RAE in a 46-year-old male patient with a history of alcoholism and pulmonary tuberculosis. Multiple, rapidly progressive, itching and burning, and focally confluent cutaneous erythematous and pur-ple macules, plaques and nodules of various size and wide distribution appeared during a course of antituberculotic therapy. The suggested clinical diagnosis was KS. The lesions were repeatedly evaluated by biopsy. Histologically, there were poorly marginated proliferations of capillaries in the dermis which extended focally into the subcutaneous tissue. Associated erythrocyte extrava-sations, stromal hemosiderin depositions and mild chronic inflammatory infiltrates were also present in the lesion. Adnexal and neuronal extension of the lesional vessels was an intriguing finding, not described in the literatuře until now. The microscopical findings were interpreted by surgical patliologists as capillary hemangioma and as „angioblastoma of Nakagawa" (one and two times, respectively).

Key words:
reactive angioendotheliomatosis – Kaposi sarcoma – tuberculosis

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Labels
Anatomical pathology Forensic medical examiner Toxicology
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