Diagnostic methods in hypoxicischemic encephalopathy of newborns

Czech version

Authors: Eva Štěpánová ^1,2,3; Hana Wiedermannová ^4,5; David Krahulík ⁶; Pavla Hanzliková ^7,8
Authors‘ workplace: Oddělení dětské neurologie, Fakultní nemocnice Ostrava ¹; Katedra neurověd, Ostravská, univerzita, Ostrava ²; Neurologická klinika, Lékařská, fakulta, Univerzita Palackého, a Fakultní nemocnice Olomouc ³; Oddělení neonatologie, Fakultní nemocnice Ostrava ⁴; Katedra dětského lékařství, Ostravská univerzita, Ostrava ⁵; Neurochirurgická klinika, Lékařská fakulta, Univerzita, Palackého a Fakultní, nemocnice Olomouc ⁶; Ústav radiodiagnostický, Fakultní nemocnice Ostrava ⁷; Ústav zobrazovacích metod, Ostravská univerzita, Ostrava ⁸
Published in: Čes-slov Pediat 2025; 80 (1): 20-25.
Category: Comprehensive Report
doi: https://doi.org/10.55095/CSPediatrie2025/003

Overview

Štěpánová E, Wiedermannová H, Krahulík D, Hanzlíková P. Diagnostic methods in hypoxic-ischemic encephalopathy

Hypoxic-ischemic encephalopathy (Hie) is the most serious cause of neonatal morbidity and mortality; it involves damage to the brain of a full-term newborn; in premature infants, it occurs in the form of periventricular leukomalacia. the incidence of Hie is approximately 1-3 per 1000 live births worldwide. the most severe forms of Hie, according to some sources, represent up to a 60 % risk of death, therefore rapid and timely diagnosis, especially of moderate to severe forms, early transport to a perinatological center and indication of therapeutic hypothermia can mitigate and predict the consequences of asphyxiation damage. this communication aims to create an overview of current diagnostic option for Hie, especially imaging methods focusing on magnetic resonance imaging.

Keywords:

therapeutic hypothermia – examination methods – t1 relaxometry

Sources

poláčková r. průběh a účinnost léčby řízenou hypotermií u asfyktických novorozenců. [disertační práce.] olomouc: univerzita palackého v olomouci, lékařská fakulta 2018. dostupné na: https: //theses.cz/id/tispv3/
Cornet m-C, kuzniewicz m, scheffler a, et al. perinatal hypoxic-ischemic encephalopathy: incidence over time within a modern us birth cohort. pediatr neurol 2023; 149: 145–50.
Bel Vf, Groenendaal f. Birth asphyxia-induced brain damage: the long road to optimal reduction and prevention! pediatr Med 2020; 3: 3.
piredda fG, hilbert t, ravano V, et al. data-driven myelin water imaging based on t1 and t2 relaxometry. nMr Biomed 2022; 35(7).
Beck J, loron G, ancel p-y, et al. an updated overview of Mri injuries in neonatal encephalopathy: lytonepal cohort. children 2022; 9(4): 561.
trollmann r. neuromonitoring in neonatal-onset epileptic encephalopathies. Front neurol 2021; 12.
Westblad em, löwing k, Grossmann rk, et al. long-term motor development after hypothermia-treated hypoxic-ischaemic encephalopathy. eur J paediatr neurol 2023; 47: 110–17.
Janota J, straňák Z, et al. neonatologie. 3.vyd. praha, eeZy publishing 2023: 88–93
sarnat hB, flores-sarnat l, fajardo C, et al. sarnat grading scale for neonatal encepahlopathy after 45 years: an update proposal. pediatr neurol 2020; 113: 75–79.
Gomella tl, eyal fG, Bany-mohammed f (eds.). Gomella’s neonatology management, procedures, on-call problems, diseases, and drugs. 8th ed. new york: McGraw-Hill 2020: 997–1005.
poláčková r, malý J, pokorná p, straňák Z., řízená hypotermie v léčbě hypoxicko-ischemické encefalopatie (Hie) – doporučený postup České neonatologické společnosti, revize 2023. 2019.
Govaret p, de Vries s. an atlas of neonatal Brain sonography. 2nd ed. london: Mac keith edition 2010: 325.
Guan B, dai C, Zhang y, et al. early diagnosis and outcome prediction of neonatal hypoxic-ischemic encephalopathy with color doppler ultrasound. diagnostic intervention imag 2017; 98(6): 469–75.
Barkovich Jm, Williams C, Barkovich Ja. technical and practical tips for performing brain magnetic resonance imaging in premature neonates. seminar perinatol 2021; 45(7): 151468.
parmentier JeC, Vries dsl, Groenendaal f. Magnetic resonance imaging in (near-)term infants with hypoxic-ischemic encephalopathy. diagnostics 2022; 12(3): 645.
Jones ar, palasis s, Grattan-smith dJ. Mri of the neonatal brain: optimization of spin-echo parameters. am J roentgenol 2004; 182(2): 367– 72.
marques pJ, kober t, krueger G, et al. Mp2raGe, a self bias-field corrected sequence for improved segmentation and t1-mapping at high field. neuroimage 2010; 49(2): 1271–81.
Bano s, Chaudhary V, Garga u. neonatal hypoxic-ischemic encephalopathy: a radiological review. J pediatr neurosci 2017; 12(1): 1.
li y, sethi ks, Zhang C, et al. iron content in deep gray matter as a function of age using quantitative susceptibility mapping: a multicenter study. Front neurosci 2021; 14.
Beck J, loron G, ancel p-y, et al. an updated overview of Mri injuries in neonatal encephalopathy: lytonepal cohort. children 2022; 9(4): 561.
Qin x, Cheng J, Zhong y, et al. Mechanism and treatment related to oxidative stress in neonatal hypoxic-ischemic encephalopathy. Front Molecul neurosci 2019; 12.
lally Jp, montaldo p, oliveira V, et al. Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study. lancet neurol 2019; 18(1): 35–45.