Current management of pediatric patients with acute pyelonephritis in the Bratislava region

Czech version

Authors: Vladimír Harvan ¹; Patrik Konopásek ²; Jakub Zieg ³; Jakub Gécz ⁴; Marcel Brenner ⁴; Ivo Topo Ský ⁵; Ján Breza ¹; Peter Bartoň ¹; Barbora Piteková ^1,4,5
Published in: Čes-slov Pediat 2025; 80 (1): 26-29.
Category: Comprehensive Report
doi: https://doi.org/10.55095/CSPediatrie2025/004

Overview

Harvan V, Konopásek p, Zieg J, Gécz J, Brenner m, topoľský i, Breza J, Bartoň p, piteková B. Current management of pediatric patients with acute pyelonephritis in the Bratislava region

Acute pyelonephritis is a common bacterial infection in childhood. it is a concerning infection for pediatricians due to the risk of acute complications, such as urosepsis, or long-term complications, like chronic kidney disease and hypertension. proper management of pediatric patients with acute pyelonephritis significantly reduces the risk of potential complications, which is why it receives increased attention today.

Keywords:

acute pyelonephritis – Pediatrics – Escherichia coli – Urinary tract infections

Sources

tullus k, shaikh n. urinary tract infections in children. lancet 2020; 395(10237): 1659–1668. doi: 10.1016/s0140-6736(20)30676-0
kaufman J, temple-smith m, sanci l. urinary tract infections in children: an overview of diagnosis and management. BMJ paediatrics open 2019; 3(1): e000487. doi: 10.1136/bmjpo-2019-000487
Chang sl, shortliffe ld. pediatric urinary tract infections. pediatric clinics of north america 2006; 53(3), 379–400. doi: 10.1016/j.pcl.2006.02.011
montini G, tullus k, hewitt i. Febrile urinary tract infections in children. new engl Med 2011; 365(3): 239–250. doi: 10.1056/neJMra1007755
shaikh m, hoberman a. urinary tract infections in infants older than one month and children less than two years: acute management, imaging, and prognosis. 2020.
lutter sa, Currie ml, mitz lB, Greenbaum la. antibiotic resistance patterns in children hospitalized for urinary tract infections. arch pediatrics adolesc Med 2005; 159(10): 924. doi: 10.1001/archpedi.159.10.924
majumder mi, mahadi ar, ahmed t, et al. antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh. antimicrob resistance infect control 2022; 11: 156. doi: 10.1186/s13756-022-01197-6
pitekova Bk, Babelova m, Gecz J, et al. the susceptibility of escherichia coli to antibiotic treatment for pediatric patients with febrile urinary tract infections in the Bratislava region. klinische pädiatrie, eFirst. 2024. doi: 10.1055/a-2356-7784
Bell le, mattoo tk. update on childhood urinary tract infection and vesicoureteral reflux. seminars nephrol 2009; 29(4): 349–359. doi: 10.1016/j. semnephrol.2009.03.011
roberts kB. urinary tract infection: clinical practice guideline for the diagnosis and management of the initial uti in febrile infants and children 2 to 24 months. pediatrics 2011; 128(3): 595–610. doi: 10.1542/peds.2011-1330
källenius G, möllby r, hultberg h, et al. structure of carbohydrate part of receptor on human uroepithelial cells for pyelonephritogenic escherichia coli. lancet 1981; 318(8247): 604–606. doi: 10.1016/s0140- 6736(81)92743-4
shaikh n, hoberman a, hum s W, et al. development and validation of a calculator for estimating the probability of urinary tract infection in young febrile children. JaMa pediatrics 2018; 172(6): 550. doi: 10.1001/jamapediatrics.2018.0217
Chromek m, slamová Z, Bergman p, et al. the antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. nature Med 2006; 12(6): 636–641. doi: 10.1038/nm1407
petcu Ct, stehr e, isaac Jp, desai d. Management of paediatric recurrent urinary tract infections and challenges in special patient populations. austr J General pract 2021; 50(7): 458–464. doi: 10.31128/aJGp-03-21-5922
mattoo tk, shaikh n, nelson Cp. contemporary management of urinary tract infection in children. pediatrics 2021; 147(2): e2020012138. doi: 10.1542/peds.2020-012138
Zieg, J, Bébrová, e. (2015). the current view of the diagnosis and management of urinary tract infection in children. 16, 238–242.
shaikh n, Borrell Jl, evron J, leeflang mm. procalcitonin, c‐reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children. cochrane database syst rev 2015; 2015(1): cd009185. doi: 10.1002/14651858.cd009185.pub2
Bitsori m, Galanakis e. pediatric urinary tract infections: diagnosis and treatment. expert rev anti-infective ther 2012; 10(10): 1153–1164. doi: 10.1586/eri.12.99
Becknell B, schober m, korbel l, spencer Jd. the diagnosis, evaluation and treatment of acute and recurrent pediatric urinary tract infections. expert rev anti-infective ther 2015 13(1): 81–90. doi: 10.1586/14787210.2015.986097
Bonkat G, Cai t, Galeone C, et al. adherence to european association of urology Guidelines and state of the art of glycosaminoglycan therapy for the management of urinary tract infections: a narrative review and expert meeting report. european urol open sci 2022; 44: 37–45. doi: 10.1016/j. euros.2022.07.009
Beetz r, Bachmann h, Gatermann s, et al. Harnwegsinfektionen im säuglingsund kindesalter: konsensusempfehlungen zu diagnostik, therapie und prophylaxe. urologe 2007; 46(2): 112–123. doi: 10.1007/s00120-006- 1254-9
strohmeier y, hodson em, Willis ns, et al. antibiotics for acute pyelonephritis in children. cochrane database syst rev 2014; 2014(7): cd003772. doi: 10.1002/14651858.cd003772.pub4
desai s, aronson pl, shabanova V, et al.; on behalf of the Febrile young infant research collaborative. parenteral antibiotic therapy duration in young infants with bacteremic urinary tract infections. pediatrics 2019; 144(3): e20183844. doi: 10.1542/peds.2018-3844
Cheng C-h, tsau y-k, lin t-y. effective duration of antimicrobial therapy for the treatment of acute lobar nephronia. pediatrics 2006; 117(1): e84– e89. doi: 10.1542/peds.2005-0917
esposito s, Biasucci G, pasini a, et al. antibiotic resistance in paediatric febrile urinary tract infections. J Glob antimicrob resist 2022; 29: 499–506. doi: 10.1016/j.jgar.2021.11.003
shaikh n, hoberman a, keren r, et al. predictors of antimicrobial resistance among pathogens causing urinary tract infection in children. J pediatrics 2016; 171: 116–121. doi: 10.1016/j.jpeds.2015.12.044
Zaoutis t, shaikh n, fisher Bt, et al. short-course therapy for urinary tract infections in children: the scout randomized clinical trial. JaMa pediatr 2023; 177(8): 782–789. doi: 10.1001/jamapediatrics.2023.1979
montini G, tessitore a, Console k, et al.; stop trial Group. short oral antibiotic therapy for pediatric febrile urinary tract infections: a randomized trial. pediatrics 2024; 153(1): e2023062598. doi: 10.1542/peds.2023062598