Anorexia nervosa from an endocrinologist's point of view
Authors:
Novotná Dana 1; Móriová Barbora 2
Authors‘ workplace:
Pediatrická klinika, Fakultní nemocnice Brno a Masarykova univerzita
1; Psychiatrická klinika, Fakultní nemocnice Brno a Masarykova univerzita
2
Published in:
Čes-slov Pediat 2023; 78 (S3): 11-16.
Category:
Comprehensive Report
doi:
https://doi.org/10.55095/CSPediatrie2023/060
Overview
Anorexia nervosa is a complex psychiatric-metabolic-endocrine disease that has the highest mortality rate among psychiatric diseases. Almost all organs and systems are altered by this disease. Changes in the endocrine system mostly represent the body‘s adaptation to starvation, and after regaining the necessary weight and fat mass, they are spontaneously adjusted. However, it does not apply to all changes. There is a disorder of the hypothalamic-pituitary axis with manifestations of hypogonadotropic hypogonadism, hypercortisolemia, resistance to growth hormone, thyroid dysfunction, hyponatremia and hypooxytocinemia. The production of antidiuretic hormone can also be altered, and a bone metabolism disorder can be diagnosed relatively early and often persists even after recovering from anorexia nervosa. Recently, changes in the intestinal microbiome, lipid metabolism, cytokine production disorders with the development of autoimmunity, and immune function disorders have also been described.
Keywords:
anorexia nervosa, osteoporosis, hypothalamic dysfunction, euthyroid sick syndrome, food intake regulation
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2023 Issue S3
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