Perinatal outcome of SARS-CoV-2 infection in pregnancy
Authors:
Korček Peter 1,2; Urbancová Hana 3; Hadravská Šárka 4,5; Straňák Zbyněk 1,2
Authors‘ workplace:
Ústav pro péči o matku a dítě – neonatologie, Praha
1; 3. lékařská fakulta Univerzity Karlovy
2; Ústav pro péči o matku a dítě – klinická patologie, Praha
3; Bioptická laboratoř s. r. o., Plzeň
4; Šiklův ústav patologie, Fakultní nemocnice Plzeň
5
Published in:
Čes-slov Pediat 2022; 77 (1): 27-33.
Category:
Original Papers
Overview
SARS-CoV-2 placentitis is a rare and serious complication of COVID-19 disease in pregnancy. The coronavirus placental infection may lead to maternal and fetal vascular malperfusion (pregnancy itself is a prothrombotic state), fetal demise, intrauterine hypoxia, fetal growth restriction, or preterm birth with the accompanying neonatal morbidity. In case of transplacental transmission of SARS-CoV-2, newborns can also suffer from early-onset viral pneumonia. Consequently, comprehensive epidemiology control should be implemented during pregnancy (frequent testing, contact tracing, vaccination). Furthermore, anticoagulation prophylaxis (low-molecular-weight heparin) and thorough fetal surveillance may be employed in COVID-positive pregnancies, especially in highrisk cases with preexisting placental insufficiency.
Keywords:
Placenta – SARS-CoV-2 – COVID-19 – perinatology – perinatal morbidity
Sources
1. Linehan L, O’Donoghue K, Dineen S, et al. SARS-CoV-2 placentitis: An uncommon complication of maternal covid- 19. Placenta 2021; 104: 261–266.
2. Raschetti R, Vivanti AJ, Vauloup-Fellous C, et al. Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat Commun 2020; 11(1): 5164.
3. Trevisanuto D, Cavallin F, Cavicchiolo ME, et al. Coronavirus infection in neonates: a systematic review. Arch Dis Child Fetal Neonatal Ed 2021; 106(3): 330–335.
4. Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020; 370: m3320.
5. Sharps MC, Hayes DJL, Lee S, et al. A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. Placenta 2020; 101: 13–29.
6. Schwartz DA, Morotti D. Placental Pathology of covid-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2. Viruses 2020; 12(11): 1308.
7. Smithgall MC, Liu-Jarin X, Hamele-Bena D, et al. Third- -trimester placentas of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive women: histomorphology, including viral immunohistochemistry and in-situ hybridization. Histopathology 2020; 77(6): 994–999.
8. Prabhu M, Cagino K, Matthews KC, et al. Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study. BJOG 2020; 127(12): 1548–1556.
9. Gulersen M, Prasannan L, Tam Tam H, et al. Histopathologic evaluation of placentas after diagnosis of maternal severe acute respiratory syndrome coronavirus 2 infection. Am J Obstet Gynecol MFM 2020; 2(4): 100211.
10. Shanes ED, Mithal LB, Otero S, et al. Placental Pathology in Covid-19. Am J Clin Pathol 2020; 154(1): 23–32.
11. Schoenmakers S, Snijder P, Verdijk RM, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman. J Pediatric Infect Dis Soc 2021; 10(5): 556–561.
12. Mongula JE, Frenken MWE, van Lijnschoten G, et al. Covid- 19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy. Ultrasound Obstet Gynecol 2020; 56(5): 773–776.
13. Algarroba GN, Rekawek P, Vahanian SA, et al. Visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy. Am J Obstet Gynecol 2020; 223(2): 275–278.
14. Hosier H, Farhadian SF, Morotti RA, et al. SARS-CoV-2 infection of the placenta. J Clin Invest 2020; 130(9): 4947– 4953.
15. Patanè L, Morotti D, Giunta MR, et al. Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019-positive mothers and neonates at birth. Am J Obstet Gynecol MFM 2020; 2(3): 100145.
16. Facchetti F, Bugatti M, Drera E, et al. SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of placenta. EBioMedicine 2020; 59: 102951.
17. Vivanti AJ, Vauloup-Fellous C, Prevot S, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun 2020; 11(1): 3572.
18. Hecht JL, Quade B, Deshpande V, et al. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from Covid- 19-positive mothers. Mod Pathol 2020; 33(11): 2092– 2103.
19. Pique-Regi R, Romero R, Tarca AL, et al. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? Elife 2020; 9: e58716.
20. Bos M, Nikkels PGJ, Cohen D, et al. Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: A systematic review. Placenta 2018; 61: 80–88.
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2022 Issue 1
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