Langerhans histiocytosis in children
Authors:
Z. Křenová 1,2; J. Šenkyřík 2,3
Authors‘ workplace:
Klinika dětské onkologie, LF MU a FN Brno
1; LF MU, Brno
2; Klinika dětské radiologie, LF MU a FN Brno
3
Published in:
Čes-slov Pediat 2021; 76 (8): 440-446.
Category:
Original Papers
Overview
Langerhans cell histiocytosis (LCH) is the most common of the histiocytic disorders and occurs when the body accumulates too many immature Langerhans cells, a subset of the larger family of cells known as histiocytes. Scientific discussions on the definition of LCH used to be debated in terms of its classification as either an immune dysfunction or a rare cancer (neoplastic and malignant or not malignant). According to most experts, Langerhans cell histiocytosis (LCH) is currently classified as a myeloid neoplasm.
Keywords:
Langerhans histiocytosis – myeloid neoplasm – BRAFV600E mutation – LCH-associated neurodegeneration of brain
Sources
1. Rodriguez-Galindo C, et al. First line treatment of pediatric Langerhans cell histiocytosis. In: Abla Ousama, Janka Gritta (eds). Histiocytosis Disorders. Springer, 2018.
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5. Eckstein OS, Visser J, Rodriguez-Galindo C, et al. Clinical responses and persistent BRAF V600E + blood cells in children with LCH treated with MAPK pathway inhibition. Blood 2019; 133 (15): 1691–1694.
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8. McClain KL, Picarsic J, Chakraborty R, et al. CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions. Cancer 2018; 124 (12): 2607–2620.
9. Henter JI, Kvedaraite E, Martín Muñoz D, et al. Response to mitogen- activated protein kinase inhibition of neurodegeneration in Langerhans cell histiocytosis monitored by cerebrospinal fluid neurofilament light as a biomarker: a pilot study. Br J Haematol 2021. doi: 10.1111/bjh.17781.
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2021 Issue 8
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