Focal nodular hyperplasia in children – diagnostics and treatment
Authors:
S. Jaroščiaková 1; B. Frýbová 2; M. Kynčl 3; M. Grega 4; J. Šnajdauf 2; M. Rygl 2
Authors‘ workplace:
III. chirurgická klinika 1. LF Univerzity Karlovy a FN Motol, Praha
1; Klinika dětské chirurgie 2. LF Univerzity Karlovy a FN Motol, Praha
2; Klinika zobrazovacích metod 2. LF Univerzity Karlovy a FN Motol, Praha
3; Ústav patologie a molekulární medicíny 2. LF Univerzity Karlovy a FN Motol, Praha
4
Published in:
Čes-slov Pediat 2018; 73 (8): 469-474.
Category:
Overview
Focal nodular hyperplasia (FNH) is the second most frequent benign liver tumor in children. It is characterized by hepatocytic nodules separated by fibrous bands. No malignant transformation has been reported and asso- ciated complications are rare. Approximately half of the patients are asymptomatic and their lesions are detected incidentally during routine examination. The pathogenesis of FNH is unclear. The most widely accepted theory is that FNH is a hyperplastic response of hepatocytes to a localized congenital or acquired vascular anomaly. Recent reports have described an increased incidence of FNH in patients previously treated for malignancy.
There is high likelihood of malignancy in liver tumor in children, therefore an accurate diagnosis is essential. Magnetic resonance imaging is the most sensitive study for diagnostics of FNH. Conservative management is appropriate only if the patient has no symptoms and malignancy can be confidently ruled out. Surgical treatment is indicated for symptomatic patients and in case of diagnostic difficulty.
Key words:
focal nodular hyperplasia, children, magnetic resonance imaging, hepatobiliary contrast agent
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2018 Issue 8
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