Tolerogenic dendritic cells and their application in immunopathological processes
Authors:
A. Grohová 1,2,3; K. Dáňová 1,2; L. Palová-Jelínková 1
Authors‘ workplace:
SOTIO, a. s., Oddělení výzkumu, Praha
1; Ústav imunologie 2. LF UK a FN Motol, Praha
2; Pediatrická klinika 2. LF UK a FN Motol, Praha
3
Published in:
Čes-slov Pediat 2017; 72 (4): 256-262.
Category:
Review
Overview
Tolerogenic dendritic cells (tDC) are specific group of dendritic cells. At steady-state they are located in diverse tissue and play a pivotal role in maintaining central and peripheral immune tolerance. tDC restore and maintain immune homeostasis by inhibition of antigen-specific T-lymphocytes, induction of T-regulatory cells as well as B-regulatory cells and production of anti-inflammatory cytokines. tDC due to their ability to down-regulate immune response are promising tool to re-establish antigen-specific tolerance in autoimmune diseases without adverse effects of systemic immunosuppression. This interventional strategy also offers an interesting way to treat other immunopathological processes.
Key words:
tolerogenic dendritic cells, cellular therapy, immune tolerance, autoimmune disease
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Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2017 Issue 4
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