Hypertension-associated asymptomatic hyperuricaemia in the adolescents

Czech version

Authors: I. Koborová ¹; R. Kollárová ¹; Ľ. Podracká ²; M. Gajdoš ³; K. Šebeková ¹
Authors‘ workplace: Ústav molekulárnej biomedicíny, Lekárska fakulta, Univerzita Komenského, Bratislava prednosta doc. MUDr. Ing. RNDr. P. Celec, PhD., MPH ¹; Klinika detí a dorastu, Lekárska fakulta, Univerzita Pavla Jozefa Šafárika, Košice prednostka prof. MUDr. Ľ. Podracká, PhD. ²; Oddelenie klinickej a experimentálnej farmakoterapie Ústavu farmakológie, klinickej a experimentálnej farmakológie, Lekárska fakulta, Slovenská zdravotnícka univerzita, Bratislava vedúci doc. MUDr. M. Gajdoš, CSc. ³
Published in: Čes-slov Pediat 2014; 69 (3): 168-177.
Category: Review

Overview

Herein we summarize the current knowledge on the relationship between uric acid and hypertension in the adolescents. The role of uric acid as biologically active final metabolite of purine degradation pathway in humans is discussed in relation to human evolution, as well as from the pathophysiological point of view. Results of experimental, epidemiological and interventional studies suggesting causal relationship between hyperuricaemia and hypertension are presented. It is summarized that our current knowledge is insufficient to conclude whether hyperuricaemia is causally related to hypertension in the adolescents, or it merely represents a biomarker of increased risk of cardiovascular diseases or mortality. Due to lacking evidence no guidelines exist whether or not, or how, to treat hypertension associated asymptomatic hyperuricaemia. Randomized controlled prospective clinical trials are needed to confirm the potential benefits of lowering hyperuricaemia on progression of hypertension, end-organ damage, or the incidence of cardiovascular diseases.

Key words:
uric acid, purines, adolescents, hypertension, fructose, allopurinol, xantine oxidase inhibitors

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Article was published in

Czech-Slovak Pediatrics

2014 Issue 3