Monogenic Hypertension
Authors:
Z. Doležel; J. Štarha; F. Jimramovský; D. Dostálková
Authors‘ workplace:
II. dětská klinika LF MU a FN Brno
přednosta prof. MUDr. Z. Doležel, CSc.
Published in:
Čes-slov Pediat 2009; 64 (2): 89-94.
Category:
Review
Overview
Arterial hypertension (AH) is a common disorder that affects a large patient population including children. Incidence of AH in childhood is above 1%. Essential hypertension is currently the most common cause of AH in children and is usually associated with overweight or obesity.
Among disorders of secondary hypertension is monogenic hypertension caused by mutation of a single gene. This mutation leads to hyperactivity of renal sodium and chloride transporters or mineralocorticoid receptors dysfunction or dysregulation of adrenal steroids synthesis. Increased rates of sodium and water reabsorption lead to plasma volume expansion and AH. Typically, laboratory findings in monogenic forms of hypertension include low plasma renin activity. Hormonal studies coupled with genetic testing can help in the early diagnosis of these disorders as for pediatrician.
Key words:
monogenic hypertension, aldosterone, plasma renin activity, childhood
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2009 Issue 2
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