Impaired Glucose Tolerance and Diabetes in Patients with Cystic Fibrosis
Authors:
S. Koloušková; D. Zemková; J. Bartošová; Z. Šumník; V. Vávrová
Authors‘ workplace:
II. dětská klinika 2. LF UK a FN Motol, Prahapřednosta doc. MUDr. J. Vavřinec, DrSc.
Published in:
Čes-slov Pediat 2003; (5): 270-273.
Category:
Overview
Impaired glucose tolerance and diabetes mellitus (CFRD - cystic fibrosis related diabetes) are a frequentcomplication in patients with cystic fibrosis. Within the framework of CFRD screening the authors examined in122 patients above the age of 10 years without clinical symptoms of diabetes mellitus the oral glucose tolerance test(oGTT). In subjects with a pathological oGTT subsequently the intravenous glucose tolerance test was made toassess stimulated insulin secretion (FPIR; sum of insulin levels during the 1st and 3rd minute after an i.v. glucosebolus). CFRD was diagnosed in 19/122 patients (15.6%), impaired glucose tolerance in 18/122 (14.8%). A total of37/122 (30.3%) patients with impaired glucose tolerance or CFRD were diagnosed. Marked insulinopenia (FPIR< 48 mIU/l) was found in a total of 29/122 patients (23.8%), incl. 10/18 with impaired glucose tolerance. The findingof marked insulinopenia makes it possible also in patients with impaired glucose tolerance to select rationallyindividual therapeutic procedures.
Key words:
cystic fibrosis, diabetes mellitus, CFRD, impaired glucose tolerance, FPIR
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2003 Issue 5
Most read in this issue
- Septo-optic Dysplasia: Morphological, Ophthalmologic and Endocrine Findings in 11 Patients
- Biliary Atresia - Incidence and Therapeutic Results in Czech Republic
- Anti-Saccharomyces Cerevisiae Antibodies (ASCA) and Antineutrophil Cytoplasmic Antibodies(ANCA) in Children and Adolescents with Inflammatory Bowel Diseases
- Treatment of Chronic Renal Failure in Neonates, Infants and Toddlers