HIV infection – History, Pathogenesis and Clinical Manifestations
Authors:
M. Salavec 1; V. Boštíková 2; P. Boštík 3,4
Authors‘ workplace:
Katedra dermatovenerologie, LF UK Hradec Králové, Klinika nemocí kožních a pohlavních, FN Hradec Králové, přednosta doc. MUDr. Karel Ettler, CSc.
1; Katedra epidemiologie, Fakulta vojenského zdravotnictví, Univerzity obrany, Hradec Králové, vedoucí doc. MUDr. Roman Chlíbek, Ph. D.
2; Centrum pokročilých studií, Fakulta vojenského zdravotnictví Univerzity obrany, Hradec Králové, náčelník doc. MUDr. Pavel Boštík, Ph. D.
3; Klinika infekčních nemocí, LF UK a FN Hradec Králové, přednosta MUDr. Stanislav Plíšek, Ph. D.
4
Published in:
Čes-slov Derm, 86, 2011, No. 2, p. 67-81
Category:
Reviews (Continuing Medical Education)
Overview
In spite of principal efforts of physicians and researchers HIV infection remains a worldwide problem for 30 years since first cases discovery. It presents a versatile difficult problem – pathogenesis, therapy incl. possible vaccination procedures. Untreated HIV infection is a multisystemic and progressive disease resulting in almost all cases in death of patient due to immune system failure. The disease(s) principle, i.e. infection attacking immune system and leading to its gradual elimination is critical for all therapeutic efforts particularly by the fact that one can only restrictively rely on organism natural immune mechanisms at time of positive response to therapy. The current progress in therapeutic approaches changes disease features in developed countries at the same time – the rate of treated patients with “classical” course of disease as described in this article is decreased and rare manifestations presented previously in a limited way due to short survival rates of infected patients could be manifested more frequently in the contrary. This article reviews basic data and facts on HIV infection pathogenesis as presents an overview of systemic symptoms associated with AIDS with impact on skin involvement and course of other skin disorders. However this review describes only the most important specifications to understand such topic which is very extensive in every aspect. To understand further details readers are referred to other specialized literature related to HIV-AIDS.
Key words:
HIV infection – pathogenesis – clinical manifestations
Sources
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