Môže Scedosporium apiospermum spôsobiť onychomykózu?

Czech version

Authors: A. Volleková ^1,2; J. Őlvédyová ³; M. Sládeková ²; M. Lisalová ²
Authors‘ workplace: Ústav mikrobiológie, LF Slovenskej zdravotníckej univerzity, Bratislava, SR, prednosta doc. RNDr. Viktor Majtán, mim. prof. ¹; Mykologické oddelenie HPL, spol. s r. o., Bratislava, SR, riaditeľ MUDr. Juraj Hanzen ²; Neštátna dermatovenerologická ambulancia, Malacky, SR ³
Published in: Čes-slov Derm, 86, 2011, No. 2, p. 83-89
Category: Clinical and laboratory Research

Overview

Background:
Scedosporium apiospermum is known as a causal agent of systemic or subcutaneous mycoses but superficial skin infections are unusual. In 2007–2010, this fungus without dermatophytes was isolated from big toe nails of ten patients (aged 42 to 78 years) suffered from onychomycosis.

Aim:
To evaluate the role of S. apiospermum in nails.

Results:
In only one woman S. apiospermum was confirmed by direct microscopy (hyphae and typical Scedosporium conidia) and also by culture in two successive nail specimens and thus, it was regarded as etiological agent of distal-lateral onychomycosis. In other two patients with the same findings in nails, S. apiospermum might be regarded only a suspect causal agent and, also in seven cases without typical conidia the fungus was considered as a nail contaminant beacuse unrepeated mycological examination before treatment. During peroral terbinafine therapy (250 mg o.d., 12 weeks, monitored in two patients) nails improved partially and/or transitory, though onychomycosis relapsed soon after treatment.

Conclusions:
S. apiospermum may be unfrequently the etiologic agent of onychomycosis, but it is mostly found in an abnormal-appearing nails as a contaminant. Dermatologist and clinical mycologist collaboration are necessary for accurate determination of S. apiospermum role in nail plates.

Key words:
Scedosporium apiospermum – onychomycosis – etiologic agent – contaminant – terbinafine

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Labels

Dermatology & STDs Paediatric dermatology & STDs

HIV infection – History, Pathogenesis and Clinical Manifestations

Genetics of Atopic Dermatitis

Generalized Drug Eruption Following Iomeprol Coronarography

Article was published in

Czech-Slovak Dermatology

2011 Issue 2