Vliv autoplazmy obohacené o krevní destičky na tloušťku endometria a citlivost receptorů pro estrogen a progesteron
Authors:
YYuliya V. Zabrodina 1,2; Konstantin Yu. Boyarsky 3,4; Gainyl U. Akhmedyanova 1,2; Zaituna G. Khamidullina 1,2
Authors‘ workplace:
Astana Medical University, Astana, Kazakhstan
1; Department of Obstetrics and Gynecology, No. 1 Astana medical university, Astana, Kazakhstan
2; Department of Obstetrics and Gynecology, S. N. Davydov Pediatric Faculty SZGMU I. I. Mechnikov, Saint-Petersburg, Russia
3; Center for Reproduction, Genesis, Saint-Petersburg, Russia
4
Published in:
Ceska Gynekol 2024; 89(3): 203-209
Category:
Original Article
doi:
https://doi.org/10.48095/cccg2024203
Overview
Cíl: Vliv autoplazmy obohacené o krevní destičky na tloušťku endometria a citlivost receptorů na estrogen a progesteron. Materiál a metody: Do této prospektivní studie bylo zařazeno 200 pacientek. Účastnice studie byly rozděleny do dvou skupin. První, kontrolní skupina dostávala hormonální substituční terapii (HRT – hormone replacement therapy). Druhá, studijní skupina dostávala intrauterinní infuzi autoplazmy obohacené o krevní destičky (PRP – platelet-rich autoplasma). Devatenáctý den menstruačního cyklu bylo provedeno ultrazvukové vyšetření s cílem zhodnotit tloušťku endometria a dále imunohistochemická analýza k stanovení citlivosti receptorů pro estrogen a progesteron. Výsledky: Během studie jsme zjistili, že po podání autoplazmy obohacené o krevní destičky se zvýšila tloušťka endometria o 0,85 mm; průměrná tloušťka endometria ve skupině na terapii PRP byla 8,25 mm (8,25–8,61 mm) a ve skupině pacientek, které dostávaly pouze HRT, byla 7,40 mm (7,34–7,65 mm). Citlivost receptorů pro estrogen se v experimentální skupině zvýšila o 3,5, přičemž v této skupině dosáhla hodnoty 75,00 (71,43–74,22) a v kontrolní skupině 71,50 (67,05–70,85). Citlivost receptorů pro progesteron se zvýšila o 9,0, hodnota v této skupině byla 95,0 (91,4–93,8) a v kontrolní skupině 86,0 (83,47–86,27). Závěr: Díky působení destičkových faktorů má terapie PRP pozitivní vliv na endometrium, kdy zvyšuje jeho tloušťku a zlepšuje receptivitu. Je tedy možné vyvodit závěr, že tato metoda zřejmě nalezne velké praktické uplatnění při zlepšování výsledků programů asistované reprodukce.
Klíčová slova:
neplodnost – autoplazma obohacená o krevní destičky – nízké endometrium
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
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