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Comparison of prenatal ultrasound examination, post-mortem magnetic resonance imaging and autopsy (a case report – schizencephaly)


Authors: M. Vaněčková 1;  Z. Seidl 1,2;  B. Goldová 3;  I. Vítková 3;  A. Baxová 4;  P. Calda 5
Authors‘ workplace: Radiodiagnostická klinika, odd MR, 1. LF UK a VFN, Praha, přednosta prof. MUDr. J. Daneš, CSc. 1;  Vysoká škola zdravotnická, Praha, rektor prof. MUDr. Z. Seidl, CSc. 2;  Ústav patologie, 1. LF UK a VFN, Praha, přednosta prof. MUDr. C. Povýšil, DrSc. 3;  Ústav biologie a lékařské genetiky, 1. LF UK a VFN, Praha, přednosta doc. MUDr. M. Kohoutová, CSc. 4;  Gynekologicko-porodnická klinika, 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 5
Published in: Ceska Gynekol 2009; 74(3): 225-228

Overview

Objective:
To improve prenatal diagnostic with a feedback of autopsy, complemented by post mortem magnetic resonance imaging (MRI). MRI is important for malformations of CNS, where autopsy can be insufficient.

Subject:
Case report.

Setting:
MR unit of the Department of radiology, Department of obstetrics and gynaecology and Department of pathology, 1st medical school, Charles University in Prague, General Teaching Hospital.

Subject and method:
To compare prenatal ultrasound, post mortem MRI and autopsy.

Conclusion:
Case report documented complementarity of all three method; full agreement in brain malformation type was found.

Key words:
post mortem MR, autopsy, ultrasound, schizencephaly.


Sources

1. Cohen, MC., Paley, MN., Giffiths, PD., et al. Less invasive autopsy: benefits and limitations of the use of magnetic resonance imaging in the perinatal postmortem. Pediatr Dev Pathol, 2008, 11, 1, p. 1-9.

2. Garel, C. MRI of the fetal brain. Berlin Heidelberg: Springer-Verlag, 2004, p. 267.

3. Granat, T., Farina, L., Faiella, A., et al. Familian schizencephaly associated with EMX2 mutation. Neurology, 1997, 48, 5, p. 1403-1406.

4. Hayashi, N., Tsutsumi, Y., Barkovich, AJ. Morphological features and associated anomalies of schizencephaly in the clinical population: detailed analysis of MR images. Neuroradiology, 2002, 44, 5, p. 418-427.

5. Karen, Y., Kennedy, AM., Frias, A., et al. Fetal schizencephaly: pre- and postnatal imaging with a review of the clinical manifestations. RadioGraphics, 2005, 25, p. 647-657.

6. Osborn, AG., Blaser, SI., Salzman, KL., et al. Diagnostic imaging brain. Utah, Salt Lake City: Amirsys Inc, 2004.

7. Sebire, NJ. Towards the minimally invasive autopsy? Ultrasound Obstet Gynecol, 2006, 28, p. 865-867.

8. Seidl, Z., Vaněčková, M. Magnetická rezonance hlavy, mozku a páteře. Praha: Grada 2007.

9. Whitby, EH., Paley, MNJ., Cohen, M., et al. Post-mortem fetal MRI: What do we learn from it? Eur J Radiol, 2006, 57, p. 250-255.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 3

2009 Issue 3

Most read in this issue
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