Celiac Disease and Female Infertility

Czech version

Authors: Š. Machač ¹; A. Kolek ²; J. Dostál ¹; M. Procházka ¹; I. Oborná ¹; Březinová J. Svobodová M. ¹; Milan Kudela ¹
Authors‘ workplace: Centrum asistované reprodukce, Gynekologicko-porodnická klinika FN a LF UP, Olomouc, přednosta prof. MUDr. M. Kudela, CSc. 2Gastroenterologická ambulance, Dětská klinika FN a LF UP, Olomouc, přednosta doc. MUDr. V. Mihál, CSc. ¹
Published in: Ceska Gynekol 2003; (2): 80-83
Category:

Overview

Objective:
To determine incidence of subclinical forms of celiac disease in women with decreasedfertility.Design: Screening test.Setting: Department of Gynecology and Obstetrics, University Hospital, Palacký University, Olomouc.Methods: 137 patients with fertility problems were included to the study. There were divided intotwo groups, patients with infertility and patients with repeated pregnancy loss. Screening test forceliac disease, serum level of antibodies tissue transglutaminase (tTGA) were performed in all ofthem. Positive test was confirmed by serological level of anti endomysium antibodies (EmA) andfinal diagnosis of silent celiac disease was done by enterobiopsy.Results: Celiac disease was found in two infertile patients (1.67%). In one patient the silent form wasdiagnosed by enterobiopsy. The second disease was latent form. In patients with repeated pregnancyloss we did not observe positive screening test.Conclusion: We confirmed higher incidence of celiac disease in women with impaired fertility.

Key words:
celiac disease, infertility, repeated pregnancy loss

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