Impaired Thyroid Function and Impaired Fertility

Czech version

Authors: S. Oravec ¹; S. Hlavačka ²
Authors‘ workplace: II. interná klinika LFUK-FN, Bratislava, prednosta prof. MUDr. I. Balažovjech, DrSc. 2 I. gynek. -pôrod. klinika LFUK-FN, Bratislava, prednosta doc. MUDr. M. Borovský, CSc. ¹
Published in: Ceska Gynekol 2000; (1): 53-57
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Overview

The treatment of young infertile women and women with menstrual cycle dysfunction by thyroidgland extracts and later by pure thyroid hormones led to improvement of their menstrual cycleand frequently also to desired conception. Therefore a functional connection between thyroid andovary, i.e. an effect of thyroid hormones on ovarian reproductive function was assumed.However, till recently exact scientific evidence did not exist, which could explain the functionalconnection between these two endocrine glands. The scientific discoveries of the last years in thearea of human reproduction (which continues in experimental work on the superfamily of stero-id/thyroid receptors, which have been coded by protoonkogen c-erb-A variants), presented proofof the presence of thyroid stimulating hormone (TSH) as well as of T3 -receptors in ovary and thusway of direct TSH- and T3 -effect on steroidogenesis and oocyte maturation.The authors present scientific discoveries from recent years, which seem to be crucial for theexplanation of the thyroid-ovary relation and present the treatment algorithm for practical clini-cal application of experimental knowledge of human reproduction.

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