Borna Disease Virus (BDV) and Psychical Disorders
Authors:
S. Racková 1; L. Janů 1; H. Kabíčková 2
Authors‘ workplace:
Psychiatrická klinika LF UK a FN, Plzeň
1; Klinlab, s. r. o., Ústřední vojenská nemocnice Střešovice, Praha
2
Published in:
Čes. a slov. Psychiat., 104, 2008, No. 8, pp. 426-436.
Category:
Comprehensive Reports
Overview
Description, characteristics: Borna disease virus (BDV) is a RNA virus which belongs to the family of Bornaviridae, order Mononegavirales. BDV is characterised with a high affinity to the limbic system.
Mechanism of influence:
BDV antigens bind to the neurotransmitter receptors and BDV infection increases the production of cytokines which indirectly influence the neurotransmitter systems too. BDV causes the infection of warm-blooded animals characterised with the damage of the central nervous system (CNS) with mood and behaviour changes.
BDV and psychic disorders:
The higher positivity of BDV infection is detected in patients with psychiatric disorders in comparison with the lower positivity in healthy individuals. We suppose that there is a connection between the course of psychiatric disorders and BDV infection. The virostatic medication-amantadine is used in the treatment of this infection. This treatment is connected with the faster improvement of psychic status of patients.
Key words:
BDV, psychiatric disorders, depression, schizophrenia, amantadine.
Sources
1. Berg, A. L., Berg, M.: A variant form of feline Borna disease. Journal of Comparative Patology, 119, 1998, 3, pp. 323-331.
2. Berg, A. L., Dorries, R., Berg, M.: Borna disease virus infection in racing horses with behavioral and movement disorders. Archives of Virology., 144, 1999, 3, pp. 547-559.
4. Berg, M., Johansson, M., Montell, H., Berg, A. L.: Wild birds as possible natural reservoir of Borna disease virus. Epidemiology and Infection, 127, 2001, 1, pp. 173-178.
3. Billaud, J. N., Ly, C., Phillips, T. R., Torre, J. C.: Borna disease virus persistence causes inhibition of glutamate uptake by feline primary cortical astrocytes. Journal of Virology, 74, 2000, 22, pp.10438-10446.
5. Bode, L., Durrwald, R., Rantam, F. A., Ferszt, R., Ludwig, H.: First isolates of infectious human Borna disease virus from patients with mood disorders. Molecular Psychiatry, 1, 1996, pp. 200-212.
6. Bode, L., Ludwig, H.: Borna disease virus infection, a human mental-health risk. Clinical Microbiology Reviews, 16, 2003, 3, pp. 534-545.
7. Bode, L., Reckwald, P., Severus, W. E., Stoyloff, R., Ferszt, R., Dietrich, D. E., Ludwig, H.: Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies-the key marker triplet determining infection and prevailing in severe mood disorders. Molecular Psychiatry, 6, 2001, 4, pp. 481-491.
8. Carbone, K. M., Duchala, C. S., Griffin, J. W., Kincaid, A. L., Narayan, O.: Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. Journal of Virology, 61, 1987, 11, pp. 3431-3440.
9. Dauphin, G., Legay, V., Sailleau, C., Smondack, S., Hammoumi, S., Zientara, S.: Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes). Journal of General Virology, 82, 2001, (Pt9), pp. 2199-2204.
10. Dietrich, D. E., Bode, L., Spannhuth, C. W., Lau, T., Huber, T. J., Brodhun, B., Ludwig, H., Emrich, H. M.: Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial. Bipolar Disorders, 2, 2000, pp. 65-70.
11. Dietrich, D. E., Kleinschmidt, A., Hauser, U., Schneider, U., Spannhuth, C. W., Kipp, K., Huber, T. J., Wieringa, B. M., Emrich, H. M., Johannes, S.: Word recognition memory before and after successful treatment of depression. Pharmacopsychiatry, 33, 2000, 6, pp. 221-228.
12. Dietrich, D. E., Schedlowski, M., Bode, L., Ludwig, H., Emrich, H. M.: A Viro-psycho-immunological disease-model of a subtype affective disorder. Pharmacopsychiatry, 31, 1998, pp. 77-82.
13. Durrwald, R., Ludwig, H.: Borna disease virus (BDV) a (Zoonotic?) worlwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. Journal of Veterinary Medicine, 44, 1997, 3, pp. 147-184.
14. Enbergs, H. K., Vahlenkamp, T. W., Kipar, A., Miller, H.: Experimantal infection of mice with Borna disease virus (BDV): repliaction and distribution of the virus after intracerebral infection. Journal of Neurovirology, 7, 2001, 3, pp. 272-273.
15. Ferszt, R., Kuhl, K. P., Bode, L., Severus, E. W., Winzer, B., Berghofer, A., Beelitz, G., Brodhun, B., Muller-Oerlinghausen, B., Ludwig, H.: Amantadine revisited: an open trial of amantadinesulfate treatment in chronically depressed patients with Borna disease virus infection. Pharmacopsychiatry, 32, 1999, 4, pp. 142-147.
16. Fukuda, K., Takahashi, K., Iwata, Y., Mori, N., Gonda, K., Ogawa, T., Osonoe, K., Sato, M., Ogata, S., Horimoto, T., Sawada, T., Tashiro, M., Yamaguchi, K., Niwa, S., Shigeta, S.: Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. Journal of Clinical Microbiology, 39, 2001, 2, pp. 419-429.
17. Furrer, E., Bilzer, T., Stitz, L., Planz, O.: Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis. Journal of Virology, 75, 2001, 2, pp. 943-951.
18. Grabner, A., Fischer, A.: Symptomatology and diagnosis of Borna encephalitis of horses. A case analysis of the last 13 years. Tierarztliche Praxis, 1991, pp. 68-73.
19. Gosztonyi, G., Ludwig, H.: Borna disease of horses. An immunohistological and virological study of naturally infected animals. Acta Neuropathologica, 64, 1984, 3, pp. 213-221.
20. Hagiwara, K., Kamitani, W., Takamura, S., Taniyama, H., Nakaya, T., Tanaka, H., Kirisawa, R., Iwai, H., Ikuta, K.: Detection of Borna disease virus in a pregnant mare and her fetus. Veterinary Microbiology, 72, 2000, (3-4), pp. 207-216.
21. Hallensleben, W., Staeheli, P.: Inhibition of Borna disease virus multiplication by interferon: cell line differences in susceptibility. Archives of Virology, 144, 1999, 6, pp. 1209-1216.
22. Chalmers, R. M., Thomas, D. R., Salmon, R. L.: Borna disease virus and the evidence for human pathogenicity: a systematic review. Q J Med., 98, 2005, pp. 255-274.
23. Iwata, Y., Takahashi, K., Peng, X., Fukuda, K., Ohno, K., Ogawa, T., Gonda, K., Mori, N., Niwa, S., Shigeta, S.: Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. Journal of Virology, 72, 1998, 12, pp. 10044-10049.
24. Jordan, I., Briese, T., Averett, D. R., Lipkin, W. I.: Inhibition of Borna disease virus replication by ribavirin. Journal of Virology, 73, 1999, 9, pp. 7903-7906.
25. Ludwig, H., Bode, L.: Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. Rev. Sci. Tech. Off. Int. Epiz., 19, 2000, 1, pp. 259-288.
26. Ludwig, H., Furuya, K., Bode, L., Klein, N., Durrwald, R., Lee, D. S.: Biology and neurobiology of Borna disease viruses (BDV), defined by antibodies, neutralizability and their pathogenic potential. Archives of Virology, Supplementum, 7, 1993, pp. 111-133.
27. Mizutani, T., Ogino, M., Nishino, Y., Kimura, T., Kariwa, H., Tsujimura, K., Inagaki, H., Takashima, I.: A single-tube RT-PCR method for the detection of Borna disease viral genomic RNA. Japanese Journal of Veterinary Research, 46, 1998, 2-3, pp. 73-81.
28. Okamoto, M., Hagiwara, K., Kamitani, W., Sako, T., Hirayama, K., Kirisawa, R., Tsuji, M., Ishihara, C., Iwai, H., Kobayashi, T., Tomonaga, K., Ikuta, K., Taniyama, H.: Experimantal vertical transmission of Borna disease virus in the mouse. Archives of Virology, 148, 2003, pp. 1557-1568.
29. Planz, O., Rentzsch, Ch., Batra, A., Rziha, H. J., Stitz, L.: Persistence of Borna disease virus-specific nucleic acid in blood of psychiatric patient. Lancet., 352 (9128), 1998, p. 623.
30. Rackova, S., Beran, J.: Borna disease virus-jeho vliv na vznik a průběh psychických poruch. Psychiatrie, 7, 2003, 2, pp. 149-150.
31. Reeves, N. A., Helps, C. R., Gunn-Moore, D. A., Blundell, C., Finnemore, P. L., Pearson, G. R., Harbour, D. A.: Natural Borna disease virus infection in cats in the United Kingdom. Veterinary Record, 143, 1998, 19, pp. 523-526.
32. Rott, R., Herzog, S., Fleischer, B., Winokur, A., Amsterdam, J., Dyson, W., Koprowski, H.: Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science, 228, (4700), 1985, pp. 755-756.
33. Rybakowski, F., Sawada, T., Yamaguchi, K.: Borna disease virus-reactive antibodies and recent-onset psychiatric disorders. European Psychiatry, 16, 2001, 3, pp. 191-192.
34. Salvatore, M., Morzunov, S., Schwemmle, M., Lipkin, W. I.: Borna disease virus in brains of North American and European people with schizophrenia and bipolar disorder. Lancet., 349 (9068), 1997, pp. 1813-1814.
35. Schneemann, A., Schneider, P. A., Kim, S., Lipkin, W. I.: Identification of signal sequences that control transcription of Borna disease virus a nonsegment, negative-strand RNA virus. Journal of Virology, 68, 1994, 10, pp. 6514-6522.
36. Selten, J. P., van Vliet, K., Pleyte, W., Herzog, S., Hoek, H. W., van Loon, A. M.: Borna disease virus and schizophrenia in Surinamese immigrants to the Netherlands. Medical Microbiology and Immunology, 189, 2000, 2, pp. 55-57.
37. Solbrig, M. V., Koob, George, F.: Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus. Pharmacology Biochemistry and Behavior, 74, 2003, 4, pp. 777-787.
38. Staeheli, P., Sentandreu, M., Pagenstecher, A., Hausmann, J.: Alpha/beta interferon promotes transcription and inhibits replication of Borna disease virus in persistently infected cells. Journal of Virology, 75, 2001, 17, pp. 8216-8223.
39. Stitz, L., Bilzer, T., Richt, J. A., Rott, R.: Pathogenesis of Borna disease. Archives of Virology., Supplementum, 7, 1993, pp. 135-151.
40. Stitz, L., Noske, K., Planz, O., Furrer, E, Lipkin, W. I., Bilzer, T.: A functional role for neutralizing antibodies in Borna disease: influence of virus tropism outside the central nervous system. Journal of Virology, 72, 1998, 11, pp. 8884-8892.
41. Taieb, O., Baleyte, J. M., Mazet, P., Fillet, A. M.: Borna disease virus and psychiatry. European Psychiatry, 16, 2001, 1, pp. 3-10.
42. Tsuji, K., Toyomasu, K., Imamura, Y., Maeda, H., Toyoda, T.: No association of Borna disease virus with psychiatric disorders among patients in nothern Kyushu, Japan. Journal of Medical Virology, 61, 2000, 3, pp. 336-340.
43. Vahlenkamp, T. W., Enbergs, H. K., Muller, H.: Experimental and natural Borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Veterinary Microbiology, 76, 2000, 3, pp. 229-244.
44. Volmer, R., Prat, Ch. M. A., Masson, G., Garenne, A., Gonzales-Dunia, D.: Borna disease virus infection impairs synaptic plasticity. Journal of Virology, 81, 2007, 16, pp. 8833-8837.
45. Weisman, Y., Huminer, D., Malkinson, M., Meir, R., Kliche, S., Lipkin, W. I., Pitlik, S.: Borna disease virus antibodies among workers exposed to infected ostriches. Lancet., 344 (8931), 1994, pp. 1232-1233.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2008 Issue 8
Most read in this issue
- Application of Standardized Evaluating Scales in the Nursing Process in Psychiatry
- The Position of Milnacipran in Clinical Practice
- Borna Disease Virus (BDV) and Psychical Disorders
- Possibilities of Evaluation and Scaling Aggressiveness in Psychiatric Patients by Means of Personality Questionnaires