The Val158Met Polymorphism of the Catechol-O-Methyltransferase Gene and Psychotic Symptoms in Methamphetamine Dependence
Authors:
L. Hosák 1; A. Hanušová 1; M. Beránek 2; Eva Čermáková 3
Authors‘ workplace:
Psychiatrická klinika LF UK a FN, Hradec Králové
; přednosta prof. MUDr. J. Libiger, CSc.
Ústav klinické biochemie a diagnostiky LF UK a FN, Hradec Králové
1; přednosta prof. MUDr. V. Palička, CSc.
Oddělení výpočetní techniky, Ústav lékařské biofyziky LF UK, Hradec Králové
2; přednosta doc. Ing. J. Hanuš, CSc.
3
Published in:
Čes. a slov. Psychiat., 104, 2008, No. 3, pp. 109-114.
Category:
Original Article
Overview
Background:
The risk of psychotic symptoms in methamphetamine dependent individuals is eleven times higher as compared to the general population. Dopamine, which is one of the key neurotransmitters in etiopathogenesis of psychosis, is metabolised by catechol-O-methyltransferase (COMT). The COMT gene Val158Met polymorphism changes activity of the COMT enzyme up to fourfold and thus influences the dopamine activity in the brain. The aim of the study was to ascertain whether subjects dependent on methamphetamine with psychotic symptoms significantly differ from methamphetamine dependent individuals without psychosis in the Val158Met COMT genotype or allele frequency.
Methods:
Methamphetamine dependent inpatients who had signed the informed consent were enrolled into the study. We assessed psychotic symptoms according to the ICD-10 classification of mental disorders (Dgs F15.50 to F15.53). The COMT genotype was detected by the PCR (polymerase chain reaction).
Results:
Eighty-three patients (25 women) at the age of 18–38 years (median 22 years) dependent on methamphetamine entered the study. We found psychotic symptoms in 18 subjects (8 women). No significant association between psychosis in methamphetamine dependence and the Val158Met COMT genotype or allele frequency was proved (P = N.S.; Fisher´s Exact Test).
Conclusions:
Our results may have been influenced by the joint assessment of males and females in one sample, hidden ethnic stratification or interaction of the Val158Met COMT gene polymorphism with other genes and environmental factors.
Key words:
methamphetamine dependence, psychosis, dopamine, catechol-O-methyltransferase; COMT gene Val158Met polymorphism.
Sources
1. Beránek, M., Horáček, J., Palička, V.: Rapid genotyping of catechol-O-methyltransferase polymorphism using real-time PCR with fluorescent hybridization probes. Klin. Biochem. Metab., 12, 2004, pp. 145-146.
2. Berger, M., Stassen, H. H., Köhler, K., Krane, V., Mönks, D., Wanner, C., Hoffmann, K., Hoffmann, M. M., Zimmer, M., Bickeböller, H., Lindner, T. H.: Hidden population substructures in an apparently homogenous population bias association studies. Eur. J. Hum. Genet., 14, 2006, pp. 236-244.
3. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H.: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 2003, pp. 386-389.
4. DeLisi, L. E., Faraone, S. V.: When is a „Positive“ Association Truly a „Positive“ in Psychiatric Genetics? Am. J. Med. Genet. (Neuropsychiatr Genet), 141B, 2006, pp. 319-322.
5. De Oliveira, I. R., Juruena, M. F.: Treatment of psychosis: 30 years of progress. J. Clin. Pharm. Ther., 31, 2006, pp. 523-534.
6. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E.: Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl. Acad Sci USA, 98, 2001, pp. 6917-6922.
7. Freedman, M. L., Reich, D., Penney, K. L. McDonald, K. J., Mignault, A. A., Patterson, N.: Assessing the impact of population stratification on genetic association studies. Nat. Genet., 36, 2004, pp. 388-393.
8. Gelernter, J., Panhuysen, C., Wilcox, M., Hesselbrock, V., Rounsaville, B., Poling, J.: Genomewide linkage scan for opioid dependence and related traits. Am. J. Hum. Genet., 78, 2006, pp. 759-769.
9. Gottesman, I. I., Gould, T. D.: The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry, 160, 2003, pp. 636-645.
10. Hallikainen, T., Lachman, H., Saito, T., Volavka, J., Kauhanen, J., Salonen, J. T.: Lack of association between the functional variant of the catechol-O-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior. Am. J. Med Genet (Neuropsychiatr Genet), 96, 2000, pp. 348-352.
11. Helgason, A., Yngvadottir, B., Hrafnkelsson, B., Gulcher, J., Stefansson, K.: An Icelandic example of the impact of population structure on association studies. Nat. Genet., 37, 2005, pp. 90-95.
12. Hosák, L.: Role of the COMT gene Val158Met polymorphism in mental disorders: A review. Eur. Psychiatr., 22, 2007, pp. 276-281.
13. Kalina, K., Dvořák, D., Frouzová, M., Hajný, M., Minařík, J., Miovský, M., Nešpor, K.: Mezioborový glosář pojmů z oblasti drog a drogových závislostí. 1. vyd., Praha : FILIA NOVA, 2001. 98 s., ISBN 80-238-8014-4.
14. Kalivas, P. W.: Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res. Rev., 18, 1993, pp. 75-113.
15. Kunugi, H., Vallada, H. P., Sham, P. C., Hoda, F., Arranz, M. J., Li, T.: Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatr. Genet., 7, 1997, pp. 97-101.
16. Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.M., Szumlanski, C. L., Weinshilboum, R. M.: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 1996, pp. 243-250.
17. Li, T., Chen, C. K., Hu, X., Ball, D., Lin, S. K., Chen, W.: Association analysis of the DRD4 and COMT genes in methamphetamine abuse. Am. J. Med. Genet. (Neuropsychiatr Genet), 129B, 2004, pp. 120-124.
18. Lindley, S. E., Carlson, E., Sheikh, J.: Psychotic symptoms in posttraumatic stress disorder. CNS Spectr., 5, 2000, pp. 52-57.
19. McKetin, R., McLaren, J., Luxman, D.I., Hides, L.: The prevalence of psychotic symptoms among methamphetamine users. Addiction, 101, 2006, pp. 1473-1478.
20. Mravčík, V., Chomynová, P., Orlíková, B., Škrdlantová, E., Trojáčková, A., Petroš, O., Vopravil, J., Vacek, J.: Výroční zpráva o stavu ve věcech drog v České republice v roce 2006. 1. vyd., Praha: Úřad vlády ČR, 2007. 122 s., ISBN 978-80-87041-22-2.
21. Nešpor, K.: Návykové nemoci. In Höschl, C. aj.: Psychiatrie. Praha: TIGIS, 2002, s. 555-576.
22. Palmatier, M. A., Kang, A. M., Kidd, K. K.: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol. Psychiatry, 46, 1999, pp. 557-567.
23. Sazci, A., Ergul, E., Kucukali, I., Kilic, G., Kaya, G., Kara, I.: Catechol-O-methyltransferase gene Val108/158Met polymorphism, and susceptibility to schizophrenia: association is more significant in women. Mol. Brain Res., 132, 2004, pp. 51-56.
24. Spielman, R. S., McGinnis, R. E., Ewens, W. J.: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet., 52, 1993, pp. 506-516.
25. Světová zdravotnická organizace: Mezinárodní klasifikace nemocí. 10. revize. Duševní poruchy a poruchy chování. 1. vyd., Praha, Psychiatrické centrum Praha, 1992, 282 s., ISBN 80-85121-37-9.
26. Šerý, O., Hladilová, R., Zvolský, P.: Gen pro COMT ovlivňuje dispozice k alkoholismu u mužů České republiky. Čes. a slov. psychiat., 100, 2004, s. 339-342.
27. United Nations. Office on drugs and crime: World Drug Report 2004. 1st Ed. Vienna: United Nations, 2004. 210 p., ISBN 92-1-148185-6.
28. Urban, A., Kremláček, J., Libiger, J.: „Mismatch negativity“ u pacientů se schizofrenií. Psychiatrie, 9, 2005, s. 291-296.
29. Vandenbergh, D. J., Rodriguez, L. A., Miller, I. T., Uhl, G. R., Lachman, H. M.: High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers. Am. J. Med. Genet. (Neuropsychiatr Genet), 74, 1997, pp. 439-442.
30. Vevera, J., Stopková, R., Bess, M., Albrecht, T., Papežová, H., Žukov, I.: COMT polymorphism in prisoners with antisocial personality disorder. Eur. Psychiatr., 21, 2006, p. 247.
31. Volavka, J., Kennedy, J. L., Ni, X., Czobor, P., Nolan, K., Sheitman, B.: COMT158 polymorphism and hostility. Am. J. Med. Genet. (Neuropsychiatr Genet), 127B, 2004, pp. 28-29.
32. Xie, T., Ho, S. L., Ramsden, D.: Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol. Pharmacol, 56, 1999, pp. 31-38.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2008 Issue 3
Most read in this issue
- The Val158Met Polymorphism of the Catechol-O-Methyltransferase Gene and Psychotic Symptoms in Methamphetamine Dependence
- A Historical Review of Development of the Concept of Congruence
- Color Vision Deficiency in Alcoholics and its Relationship with the BDNF Polymorphism