The Role of Glutamatergic Neurotransmission in Pathophysiology of Schizophrenia

Czech version

Authors: J. Hons
Authors‘ workplace: Psychiatrická klinika LF UK a FN Hradec Králové, přednosta prof. MUDr. J. Libiger, CSc.
Published in: Čes. a slov. Psychiat., , 2004, No. 4, pp. 220-228.
Category:

Overview

The dysfunction of the neurons containing excitatory amino acids is present in a wide range ofneurodegenerative disorders. Schizophrenia may also result from a dysfunction of excitatoryamino acid neurotransmission. There are two glutamatergic hypotheses of schizophrenia.Glutamate hypofunction hypothesis supposes hypofunction of cerebral glutamatergic neuronsin schizophrenia. The most signifi cant consequence of the hypothesis is a possible use of drugsenhancing glutamatergic neurotransmission in the treatment of schizophrenic symptoms.Glutamate hyperfunction hypothesis was also proposed. It suggests a possible effect of glutamaterelease-inhibiting drugs in schizophrenia.

Key words:
glutamate, schizophrenia, glutamatergic hypothesis, NMDA receptor.

Full text is not available online.

If interested in a scan of this journal, contact NTO ČLS JEP.

Labels

Addictology Paediatric psychiatry Psychiatry

Moclobemide in the Therapy of ErectionDysfunctions

Is it Possible to Diagnose Pseudoseizures (Non-epilepticPsychogenic Seizures) by Dissociative Experience Scale (DES)?

Primary and Secondary Processes in Guided Affective Imagery

Frontotemporal Dementia

Therapy of Bipolar Depression

Quetiapine as Treatment of Severe Depressive Disorder

Article was published in

Czech and Slovak Psychiatry

2004 Issue 4