Immunopathogenesis of neuromyelitis optica

Czech version

Authors: J. Krejsek
Authors‘ workplace: Ústav klinické imunologie a alergologie, prof. RNDr. Jan Krejsek, CSc., Ústav klinické imunologie, a alergologie, LF UK a FN Hradec Králové ; 05 Hradec Králové, e-mail: jan. krejsek@fnhk. czLF UK a FN Hradec Králové ⁵⁰⁰; Sokolská tř. ⁵⁸¹
Published in: Cesk Slov Neurol N 2020; 83/116(supplementum 1): 11-14
doi: https://doi.org/10.14735/amcsnn2020S11

Overview

Neuromyelitis optica (NMO) is an autoimmune, demyelinating disorder of the CNS with typical clinical manifestations of optic neuritis and myelitis attacks. NMO is now considered an independent disease characterized by the presence of autoantibodies in IgG class reacting with aquaporin-4. These autoantibodies are currently regarded as a specific biomarker of NMO and NMO spectrum disorders. Aquaporin-4 IgG antibodies are playing a key role in the pathogenesis of NMO. Nevertheless, these autoantibodies are not present in approximately a quarter of NMO patients suggesting possible participation of other factors in the NMO immunopathogenesis which have to be elucidated.

Keywords:

neuromyelitis optica – optic neuritis – aquaporin-4 – Autoantibodies

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