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Microscopic detection of Cryptococcus in the cerebrospinal fluid as the first symptom of the advanced stage of AIDS – a case study


Authors: M. Dastych 1;  Z. Čermáková 1;  P. Štourač 3;  A. Ševčíková 2;  I. Kocmanová 2;  S. Snopková 4
Authors‘ workplace: Oddělení klinické biochemie a hematologie FN Brno a Katedra laboratorních metod LF MU 1;  Oddělení klinické mikrobiologie FN Brno 2;  Neurologická klinika FN Brno a LF MU 3;  Klinika infekčních chorob FN Brno a LF MU 4
Published in: Cesk Slov Neurol N 2008; 71/104(1): 93-96
Category: Case Report

Overview

Opportune infections may be the first serious symptom pointing to the underlying disease in persons with T lymphocyte immunodeficiency. The case study describes the occurrence of Cryptococcus meningitis as the first symptom of advanced HIV/AIDS disease. The diagnosis resulted from a rigorous cytological examination of the cerebrospinal fluid. The microscopic finding was confirmed by a latex test and cultivation with massive growth of Cryptococcus neoformans. Subsequently, HIV/AIDS was diagnosed, with anamnestically documented risk homosexual and heterosexual activit.

Key words:
cryptococcal meningitis – opportunistic infections – cerebrospinal fluid – HIV/AIDS


Sources

1) Prasad KN, Agarwal J, Nag VL, Verma AK, Dixit AK, Ayyagari A. Cryptococcal infection in patients with clinically diagnosed menigitis in a tertiary care center. Neurology India 2003; 51: 364-366.

2) Chakrabarti A, Sharma A, Sood A, Grover R, Sakhuja V, Prabhakar S et al. Changing scenario of cryptococcosis in a tertiary care hospital in north India. Indian J Med Res 2000; 112: 56-60.

3) Khanna N, Chandramuki A, Desai A, Ravi V. Cryptococcal infections of the central nervous system: an analysis of predisposing factors, laboratoty findings and outcoume in patients from South India with special reference to HIV infection. J Med Microbiol 1996; 45: 346-379.

4) Kris Ann K. Oursler, D´Moore R, Chaison RE. Risk factors for cryptococcal meningitis in HIV-infected patients. Aids Research and Human Retroviruses 1999; 15: 625-631.

5) Kalra SP, Chadha DS, Singh AP, Sanchetee PC, Mohapatra AK. Cryptococcal meningitis in acquired immunodeficiency syndrome. J Assoc Physicians India 1999; 47: 958-961.

6) Moreira Tde A, Ferreira MS, Ribas RM, Borges AS. Cryptococcosis: clinical epidemiological laboratorial study and fungi varieties in 96 patients. Rev Soc Bras Med Trop 2006; 39: 255-258.

7) Likasitwattanakul S, Poneprasert B, Sirisanthana V. Cryptococcosis in HIV-infected children. Southeast Asian J Trop Med Public Health 2004; 35: 935-9359.

8) Lakshmi V, Sudha T, Tejda VD, Umabal P. Prevalence of central nervous system cryptococcosis in human immunodeficiency virus reactive hospitalized patients. Indian J Med Microbiol 2007; 25: 146-149.

9) Brůčková M, Malý M, Vandasová J. Výskyt a šíření HIV/AIDS v ČR v roce 2006. Zprávy CEM (SZÚ, Praha) 2007; 16: 36-40.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 1

2008 Issue 1

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