Serum amyloid A and its clinical significance
Authors:
K. Vilímová 1; O. Michnová 1; P. Kušnierová 1,2
Authors‘ workplace:
Ústav laboratorní medicíny, Oddělení klinické biochemie, Fakultní nemocnice Ostrava, Ostrava
1; Ústav laboratorní medicíny, Lékařská fakulta, Ostravská univerzita, Ostrava
2
Published in:
Klin. Biochem. Metab., 30, 2022, No. 4, p. 111-116
Overview
Serum amyloid A (SAA) is one of the acute phase reactants. Its concentration in the organism rises in response to various stimuli, whether of infectious or non-infectious origin. SAA is an apolipoprotein that interacts with HDL, promotes the accumulation of leukocytes at the site of inflammation and the adhesion of platelets and participates in the removal of damaged cell membranes. SAA is water-insoluble, as is its precursor protein, which forms amyloid A deposits in various organs. Although the SAA value drops back to the minimum value after the reaction subsides, the organism no longer removes the amyloid A deposits from the tissues. Accumulation of amyloid in tissues results in their damage and limitation of function, and in the worst cases, leads to their failure. The formation of deposits in the tissues of organs is the basis of disease called amyloidosis.
Keywords:
serum amyloid A – Amyloidosis – inflammatory biomarker
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Clinical Biochemistry and Metabolism
2022 Issue 4
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