Eprosartan – dual blocker of AT₁ receptors

Czech version

Authors: J. Špinar ¹; J. Vítovec ²; L. Špinarová ²
Authors‘ workplace: Interní kardiologická klinika FN Brno, LF MU a ICRC, Brno ¹; I. interní kardioangiologická klinika FN u sv. Anny, LF MU a ICRC, Brno ²
Published in: Kardiol Rev Int Med 2012, 14(2): 121-125
Category: Reports from Foreign countries

Overview

Eprosartan – dual blocker of AT₁ receptors. AII antagonists were first recommended for the treatment of hypertension for diabetics and patients with microalbuminuria. Ten years ago, the results of four major clinical studies with AIIA were presented and published. These studies demonstrated a significant renoprotective effect of these medicaments in comparison with a placebo (RENAAL and IRMA) and amlodipine (MARVAL and IDNT). In 2002, the results of two major comparative studies into hypertension – Losartan Intervention For Endpoints (LIFE) and the Study on COgnition and Prognosis in Elderly hypertensives (SCOPE). The year 2005 saw the publication of the results of the Morbidity and mortality after strokes, eprosartan compared with nitrendipine for secondary prevention (MOSES), which brought new indicators for sartans – systolic hypertension and the secondary prevention of strokes. The ONTARGET study into the secondary prevention of ischemic heart disease was published in 2008, the same year that the OSCAR study shows the significance of the treatment of systolic blood pressure using eprosartan in the prevention of dementia. The MOSES study compared eprosartan with nitrendipine in 1,405 patients for the secondary prevention of strokes. Randomisation was successful, with minimal differences shown in basic characteristics. Blood pressure was lowered to a comparable level, without significant differences between either group over the entire duration of the monitored period (150.7/84 mmHg and 152.0/87.2 mmHg, with a reduction to 137.5/80.8 mmHg and 136.0/80.2 mmHg respectively following the administration of eprosartan and nitrendipine). Furthermore, average normotensive values were achieved after as little as 3 months and 75.5% of cases achieved values of < 140/90 mmHg following the administration of eprosartan and 77.7% following the administration of nitrendipine. During the subsequent period, a total of 461 primary incidents occurred: 206 in patients with eprosartan and 255 in patients with nitrendipine (95% CI, 0.66–0.96; p = 0.014), with the following instance of cardiovascular events: 77 for eprosartan and 101 for nitrendipine (95% CI, 0.55–1.02; p = 0.06), cerebrovascular events: 102 for eprosartan and 134 for nitrendipine (95% CI, 0.58–0.97; p = 0.03).

Keywords:
AII antagonists – eprosartan – systolic hypertension – secondary prevention of strokes

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