Sevofluran
Authors:
V. Dostálová
Authors‘ workplace:
Fakultní nemocnice Hradec Králové
; Univerzita Karlova
; Lékařská fakulta v Hradci Králové
; Klinika anesteziologie, resuscitace a intenzivní medicíny
Published in:
Anest. intenziv. Med., 31, 2020, č. Supplementum A, s. 7-13
Overview
Sevoflurane is a halogenated inhalational anesthetic used for the induction and maintenance of general anesthesia in adults and pediatric patients for inpatient and outpatient surgery. Sevoflurane is a volatile anesthetic that provides hypnosis, amnesia, analgesia, immobilization, and autonomic blockade during surgical and procedural interventions It is a volatile, non- -flammable, and non-irritant compound with a low solubility and blood-to-gas partition coefficient. Sevoflurane enhances inhibitory postsynaptic channel activity on gamma-aminobutyric acid and glycine and inhibits excitatory synaptic channel aktivity on N-methyl-D-aspartate, nicotinic acetylcholine, serotonine, and glutamate receptors in the central nervous system. Sevoflurane is delivered to the respirátory systém via a sevoflurane specific calibrated vaporizer attached to an anesthesia machine. Sevoflurane undergoes minimal hepatic metabolism or renal excretion.
Keywords:
sevoflurane – inhalation anesthetics
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Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
2020 Issue Supplementum A
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