Examination of circulating tumor cells in renal carcinoma

Czech version

Authors: Petr Klézl ¹; Jindřich Šonský ¹; Eliška Pospíšilová ²; Katarína Kološtová ²; Vladimír Bobek ^2,3; Robert Grill ¹
Authors‘ workplace: Urologická klinika FN Královské Vinohrady a 3. LF UK, Praha ¹; Oddělení laboratorní diagnostiky, laboratorní genetika, 3. LF UK a FN Královské Vinohrady, Praha ²; III. chirurgická klinika 1. LF UK Praha a FN Motol, Praha ³
Published in: Ces Urol 2020; 24(2): 100-104
Category: Review article

Zařazení vyšetření na cirkulující nádorové buňky do běžného algoritmu vyšetření u pacientů po operaci ledviny pro nádor by se mohlo stát nenahraditelným zdrojem informací vypovídajících o heterogenitě a vývoji nádoru v průběhu onemocnění. Vyšetření na přítomnost cirkulujících nádorových buněk spadá do skupiny takzvaných tekutých biopsií, jejichž neopomenutelnou výhodou je jejich minimální invazivnost při získávání vzorku (odběr periferní krve), které umožňuje sledování vývoje tumoru. Dále je možné u pacientů s cirkulujícími nádorovými buňkami podstupujících operaci pro karcinom ledviny vyšetřit molekulární charakter cirkulujících buněk zhodnocením analýzy genové exprese.

Overview

Serial examination of circulating tumor cell presence after renal cancer surgery could become an irreplaceable source of information reporting on tumor heterogeneity and evolution in time. Test for presence of circulating tumor cells belongs to the group of liquid biopsy tests and one of its main advantages is the relatively minimal invasiveness (blood withdrawal), which indeed enables tumor dynamics follow-up. Besides circulating tumor cells the presence in patients with renal cell carcinoma undergoing surgery, molecular character of circulating cells can be evaluated by gene expression analysis.

Keywords:

Renal cell carcinoma – circulating tumor cells – liquid biopsy – Gene expression – circulating tumor microemboli

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