Neuropsychiatric symptoms as early manifestation of Alzheimer’s disease

Czech version

Authors: V. Matušková; T. Nikolai; H. Marková; K. Čechová; J. Laczó; J. Hort; M. Vyhnálek
Authors‘ workplace: Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně ; Neurologická klinika 2. LF UK a FN Motol, Praha
Published in: Cesk Slov Neurol N 2020; 83(1): 64-72
Category: Original Paper
doi: https://doi.org/10.14735/amcsnn202064

Neuropsychiatrické symptomy (NPS) jsou heterogenní skupina změn v osobnosti a chování, které lze pozorovat již v časných stadiích Alzheimerovy nemoci (AN). Mírná behaviorální porucha (mild behavioral impairment; MBI) je nová diagnostická kategorie popisující trvalé změny v osobnosti a chování s počátkem v pozdější fázi života. Na podkladě těchto kritérií byl vytvořen nový Dotazník mírné poruchy chování (Mild Behavioral Impairment Checklist; MBI-C) zaměřený na detekci NPS v časných stadiích AN. Cílem studie je představit námi adaptovanou českou verzi dotazníku MBI-C a studovat přítomnost a závažnost NPS na pilotním souboru pacientů.

Overview

Aim: Neuropsychiatric symptoms (NPS) are a heterogeneous group of changes in personality and behavior that can be observed already in early stages of Alzheimer’s disease (AD). Mild behavioral impairment (MBI) is a newly developed diagnostic category describing persistent changes in personality and behavior starting later in life. Based on these criteria, a new measure, the Mild Behavioral Impairment Checklist (MBI-C) has been developed, aimed at detecting NPS in early stages of AD. The aim of this study is to present the newly adapted Czech version of the MBI-C and to explore the presence of NPS in a pilot group of patients.

Patients and methods: The original MBI-C has been adapted to Czech and administered to close informants of 188 patients. The patients were divided according to the results of a complex neuropsychological, neurological examination and brain imaging into 3 groups: cognitively normal (N = 69), amnestic mild cognitive impairment (aMCI; N = 87) and dementia due to AD (N = 32).

Results: Patients with aMCI expressed in the MBI-C significantly more severe score compared to cognitively normal subjects and less severe compared to dementia patients. The differences were observed mainly in affective, motivation and impulse control domains.

Conclusion: The Czech version of the MBI-C detects the presence of NPS even before the onset of dementia syndrome and is useful in clinical practice.

Keywords:

mild cognitive impairment – neuropsychiatric symptoms – Alzheimer´s disease – mild behavioral impairment

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