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Hypotension during treatment with sacubitril/valsartan: practical tips for prevention and management

27. 11. 2020 Source: Chronic Heart Failure and Lipidology

Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most common of these is hypotension. Although it is an unpleasant complication, it does not –⁠ and should not –⁠ always be a reason to discontinue therapy. Fear of hypotension should not lead to not prescribing sacubitril/valsartan at all. We provide practical guidance on how to approach this clinical situation.

Is it possible to predict survival time based on laboratory or radiological findings in patients with IPF?

High-resolution computed tomography (HRCT) imaging of the lungs is a fundamental examination in…
26. 11. 2020 Source: Pulmonary Fibrosis
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Gliflozins in the Treatment of Type 2 Diabetes According to Current Recommendations SVL

Gliflozins are a relatively new group of antidiabetics with a specific mechanism of action. In…
24. 11. 2020 Source: Diabetes
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Combination of Arterial Hypertension and Increased Heart Rate as a Significant Cardiovascular Risk Factor

Heart rate is one of the basic vital signs that should be regularly measured. Sinus tachycardia can…
23. 11. 2020 Source: Cardiovascular Continuum
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Is Six Months of Adjuvant Targeted Therapy Sufficient for Early Breast Cancer?

The inclusion of adjuvant targeted therapy with chemotherapy for early HER2-positive breast cancer…
23. 11. 2020 Source: Breast Carcinoma
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Targeted Treatment of Metastatic Breast Cancer in the 2nd Line –⁠ Experiences from Practice

The recommended treatment for metastatic HER2-positive breast cancer in the 1st line involves dual…
23. 11. 2020 Source: Breast Carcinoma
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Micronutrients in Parenteral Nutrition in Adult Patients –⁠ Current Issues and Consensus

Micronutrients are a key nutritional component, and this is also true for patients whose condition…
23. 11. 2020 Source: Parenteral Nutrition
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Residual Pulmonary Hypertension After Endarterectomy: How Common Is It?

Pulmonary endarterectomy is the only potentially curative option in the treatment of chronic…
23. 11. 2020 Source: Pulmonary hypertension (CTEPH, PAH)
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Medium to Long-term Results of PFC Sigma Total Knee Arthroplasty

The PFC Sigma knee implant was introduced in 1997. It is the most commonly used system for total…
23. 11. 2020 Source: Large Joints
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Venous Insufficiency of the Lower Extremities –⁠ A Diverse Range of Risks, Manifestations, and Complications

Although initially often asymptomatic, chronic venous insufficiency includes a variety of symptoms.…
20. 11. 2020 Source: Venous Insufficiency
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