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Trazodone with Extended Release Improves Patient Compliance

20. 5. 2020 Source: Depression and Anxiety

Since 2015, the antidepressant trazodone is available in the Czech Republic in a controlled-release formulation. A sufficiently high plasma level for 24 hours without fluctuation allows for administration only once a day, while eliminating side effects.

Ixekizumab administered for 5 years demonstrated high efficacy and a favorable safety profile in patients with moderate to severe psoriasis

Ixekizumab is a recombinant humanized monoclonal antibody against interleukin 17A, indicated for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis. At the 24th World…

19. 5. 2020 Source: Biological Treatment

Incidence of Thromboembolic Disease During Military Operations –⁠ Results of a 10-Year Review

In contemporary armed conflicts, limb injuries account for more than half of all injuries. In addition to the characteristically high incidence of infectious complications, injuries associated with…

18. 5. 2020 Source: Prevention of Thrombosis in Surgery

Comparison of Three Thromboprophylactic Regimens in Patients Post Pancreatic Surgery

Post-pancreatectomy bleeding and thromboembolic disease are among the serious complications of pancreatic surgeries. The aim of the study published last year in the British Journal of Surgery was to…

18. 5. 2020 Source: Prevention of Thrombosis in Surgery

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Do Beta-Blockers Increase the Risk of Hypoglycemia in Patients with Diabetes and Atherosclerosis?

Given that a large portion of patients with diabetes have proven cardiovascular disease, several clinical studies or their subsequent analyses address the effects of beta-blockers in these patients.…

18. 5. 2020 Source: Cardiovascular Continuum

Impact of Body Mass Index on Survival and Treatment Outcomes of Metastatic Colorectal Cancer

A pooled analysis of 25 studies with patients in the first line of treatment for metastatic colorectal cancer (mCRC) evaluated the prognostic and predictive significance of body mass index (BMI).…

17. 5. 2020 Source: Colorectal Cancer

Testing RAS Gene Mutations in Patients with Colorectal Cancer

Correct identification of the RAS oncogene variant is crucial for deciding the treatment of patients with colorectal cancer. Information on the prevalence of individual RAS gene mutations varies…

17. 5. 2020 Source: Colorectal Cancer

Reimbursement vs. Indication: Are They Clashing in Alzheimer's Disease?

Data from clinical trials and recommended procedures do not always align with insurance reimbursement criteria. Is this the case with Alzheimer's disease treatment?

17. 5. 2020 Source: Cognitive in the treatment of Alzheimer's disease

Does Dosage Frequency Matter for Adherence to Anticholinergic Treatment in Patients with COPD?

A study by Spanish authors compared the adherence of patients with chronic obstructive pulmonary disease (COPD) to anticholinergic treatment administered once every 12 hours and once every 24 hours.

15. 5. 2020 Source: Treatment of Asthma and COPD

Potential, Benefits and Proper Use of Probiotics in the Treatment of Acute Gastroenteritis in Children

Clinical studies and experiences from clinical practice have shown the benefits of administering probiotics in the treatment of acute gastroenteritis in children. Pediatrician Dr. Natália Szitányi…

15. 5. 2020 Source: GI, colic and microbiome

L. reuteri DSM 17938 in Infant Nutrition and Its Impact on the Gut Microbiota of Infants Born by Cesarean Section

The work of the Swiss-Greek team published in the Journal of Pediatric Gastroenterology and Nutrition focused on comparing the effect of infant formula containing Lactobacillus reuteri DSM 17938 on…

15. 5. 2020 Source: GI, colic and microbiome

Effective Treatment with Nivolumab in Patients with Negative PD-L1 Expression

11. 5. 2020 Source: Case Studies from Immunooncology

Characteristics of Chronic Wounds Related to Itching During Healing

Itching of wounds during healing is associated with larger wound size, more extensive tissue swelling, and the presence of granulation and necrotic tissue at the base. This was shown by an observational...

11. 5. 2020 Source: Wound Healing

Omalizumab and Treatment of Severe Refractory Asthma in Pregnant Women

Omalizumab is commonly recommended for the treatment of severe refractory asthma. A special group of patients are pregnant women with asthma, for whom the risks of inadequately treated asthma must be…

11. 5. 2020 Source: Asthma under control

Combined Treatment of Chronic Lymphocytic Leukemia in Frail Patients –⁠ Results from Real-World Clinical Practice

Treatment of older patients and those with chronic lymphocytic leukemia (CLL) who are not in good physical condition has advanced significantly in recent years. The addition of obinutuzumab to…

11. 5. 2020 Source: Non-Hodgkin Lymphomas and CLL

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