Thrombotic microangiopathy in children
Authors:
T. Šuláková 1; T. Zaoral 1; T. Seeman 1,2
Authors‘ workplace:
Klinika dětského lékařství LF OU a FN Ostrava
1; Pediatrická klinika 2. LF UK Praha
2
Published in:
Transfuze Hematol. dnes,30, 2024, No. S1, p. 16-29.
Category:
doi:
https://doi.org/10.48095/cctahd2024suppl1S16
Overview
Thrombotic microangiopathy (TMA) is a pathological lesion triggered by endothelial injury or dysfunction. TMA occurs in a wide range of diseases and is characterized by microangiopathic haemolytic anaemia, thrombocytopenia and ischemic organ injury due to thrombosis in the microvascular capillary bed. In the paediatric population, TMA occurs in both as a primary, i.e. congenital form, and a secondary, acquired form – especially linked to E. coli infection. Understanding the epidemiology, pathophysiology, laboratory and clinical signs and differential diagnosis is crucial for a timely specific therapeutic approach to this life-threatening disease.
Keywords:
Adolescents – thrombotic thrombocytopenic purpura – haemolytic uremic syndrome – thrombotic microangiopathy – children
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PODÍL NA PŘÍPRAVĚ RUKOPISU
TŠ – napsání rukopisu a jeho revize
TZ – revize + korekce rukopisu
TS – podíl na rukopisu kapitoly o infekcí podmíněné TMA, revize + korekce rukopisu
ČESTNÉ PROHLÁŠENÍ
Autoři práce prohlašují, že v souvislosti s tématem, vznikem a publikací tohoto článku nejsou ve střetu zájmů a vznik ani publikace článku nebyly podpořeny žádnou farmaceutickou firmou.
Do redakce doručeno dne: 28. 11. 2023.
Přijato po recenzi dne: 8. 7. 2024.
doc. MUDr. Mgr. Terezie Šuláková, Ph.D.
Klinika dětského lékařství
LF OU a FN Ostrava
17.listopadu 1790
708 52 0strava – Poruba
e-mail: terezie.sulakova@fno.cz
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2024 Issue S1
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