Adverse reactions during haematopoietic stem cell collection in unrelated donors – ten-year experience of the Czech National Marrow Donors Registry (ČNMDR)
Authors:
Lysák D.ihash2ihash4ihash6ihash8ihash10 1 1 1 1 1,2 1,2
Authors‘ workplace:
Hematologicko-onkologické oddělení FN Plzeň, Český národní registr dárců dřeně
1
Published in:
Transfuze Hematol. dnes,17, 2011, No. 3, p. 130-136.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
We analyzed retrospectively a group of 339 unrelated donors who underwent bone marrow (n=169) or peripheral stem cell (n=170) collection in the years 1999–2009. The required doses of haematopoietic stem cells were collected in 60 % of procedures, with no significant difference between men and women. Suboptimal grafts were obtained in 2 % of bone marrow collections and 5 % of peripheral blood stem cell collections. The frequency of adverse events was 55 % (51 % of bone marrow and 59 % of peripheral blood stem cell collections). Nausea and vomiting following general anaesthesia and pain at the aspiration site were the most common reactions in bone marrow donors. Peripheral blood stem cell collections were most frequently associated with leukopenia and thrombocytopenia. A higher incidence of adverse events was observed in women. Neither severe adverse events nor donor death associated with the collection were recorded during the observed period. The study demonstrated that the collection of haematopoietic stem cells from healthy donors is a safe procedure with a low risk of complications. The donor registry has established standard procedures for donor selection, for examinations to be conducted before collection as well as for the process of caring for donors during collection. Compliance with these rules in combination with the high professionalism of all participating health care personnel decreases the probability of severe or unexpected complications during donation.
Key words:
stem cells, allogeneic, donor, registry, adverse reaction, CD34+
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Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2011 Issue 3
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