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Donor Lymphocyte Transfusion


Authors: M. Mistrík
Authors‘ workplace: Klinika hematológie a transfuziológie FN, Bratislava
Published in: Transfuze Hematol. dnes,, 2000, No. 4, p. 137-143.
Category:

Overview

With the achievement of long-lasting allogeneic bone marrow transplants it became possible torecognize a graft-versus-leukemia effect. This positive effect is enhanced with additional transfusionof lymphocytes from the original hematopoietic stem cell donor alone and can reinduce long-lastingremissions and achieve possible leukemia relapse cure. Many blood and marrow transplantation teamsare exploring donor lymphocyte transfusion use for therapy against tumor-specific antigens, forenhancing the defense against infections, or for correction of an ailing immune system. The appropriatecell dose remains unsettled. The graft-versus-leukemia (GVL) effect of allogeneic donor lymphocytetransfusion is associated with graft-versus-host disease (GVHD) and myelosuppression, and the pre-vention of these complications is a continuing matter of concern. It seems likely that in the future,further refinements in the separation of GVL from GVHD will ensure that allogeneic BMT willincreasingly be used as a tool to procure an effective leukemia relapse profylaxis.

Key words:
donor lymphocyte transfusion, graft versus leukemia effect, leukemia relapse, graft versushost disease

Full text is not available online.
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Labels
Haematology Internal medicine Clinical oncology
Topics Journals
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