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Summary of the skin substitute revolution – skin coverings in the modern era of healthcare

Czech version

Authors: J. Bartková 1,2;  E. Horálková 1,2;  V. Barčinová 2;  R. Hrušovská 2
Authors‘ workplace: Klinika popálenin a plastické chirurgie, Brno, Česká republika 1;  Lékařská fakulta Masarykovy university, Brno, Česká republika 2
Published in: Rozhl. Chir., 2024, roč. 103, č. 6, s. 202-207.
Category: Review
doi: https://doi.org/10.33699/PIS.2024.103.6.202–207

Overview

Skin substitutes and covers are crucial across surgical disciplines, promoting interdisciplinary collaboration to meet varied clinical needs. While some medical professionals may encounter these products infrequently in their practice, understanding their properties and applications is paramount to provide optimal patient care. In this overview, we aim to provide healthcare professionals with essential information regarding skin substitutes and covers, equipping them with knowledge to navigate their use effectively across different clinical scenarios and to optimize patient outcomes. The speed of progress in tissue engineering and regenerative medicine is notable, driven by collaborative efforts among scientists, engineers, and clinicians. Technological advancements, increased funding, and a deeper understanding of cellular and molecular processes have accelerated research and development. However, challenges remain, such as achieving vascularization in engineered tissues, addressing immune responses, and ensuring long-term functionality of regenerated organs. Despite these hurdles, the field continues to evolve rapidly, offering hope for transformative medical solutions that may redefine the treatment landscape soon. In this article, we review the current selected commercially available epidermal, dermal, and total skin substitutes for wound healing.

Keywords:

Wound healing – Tissue engineering – skin covers – epidermal substitutes – dermal substitutes

Sources
  1. Church D, Elsayed S, Reid O, et al. Burn wound infections. Clinical Microbiology Reviews 2006;19(2):403–434. doi:10.1128/CMR.19.2.403-434.2006.
  2. Al-Himdani S, Jessop ZM, Al-Sabah A, et al. Tissue-engineered solutions in plastic and reconstructive surgery: Principles and practice. Front Surg. 2017;4:4. doi:10.3389/fsurg.2017.00004.
  3. Ikada Y. Challenges in tissue engineering. J R Soc Interface. 2006;3(10):589–601. doi:10.1098/rsif.2006.0124.
  4. Sharma P, Kumar P, Sharma R, et al. Tissue engineering; current status & futuristic scope. J Med Life 2019;12(3):225–229. doi:10.25122/jml-2019-0032.
  5. Al-Himdani S, Jessop ZM, Al-Sabah A, et al. Tissue-engineered solutions in plastic and reconstructive surgery: Principles and practice. Front Surg. 2017;4:4. doi:10.3389/fsurg.2017.00004.
  6. Awad HA, O’Keefe RJ, Lee CH, et al. Chapter 83 – bone tissue engineering: Clinical challenges and emergent advances in orthopedic and craniofacial surgery. ScienceDirect 2014. doi:10.1016/B978-0-12-398358-9.00083-5.
  7. Dabra S, Chhina K, Soni N, et al. Tissue engineering in periodontal regeneration: A brief review. Dental Research Journal 2012;9(6):671–680.
  8. Atala A, Lanza R. Methods of tissue engineering. Gulf Professional Publishing 2001.
  9. Lanza R, Langer R, Vacanti JP, et al., eds. Principles of tissue engineering. Academic Press 2020.
  10. Sampogna G, Guraya SY, Forgione A. Regenerative medicine: Historical roots and potential strategies in modern medicine. J Microsc Ultrastruct. 2015;3(3):101–107. doi:10.1016/j.jmau.2015.05.002.
  11. Veţţammāņi. Purāņic encyclopaedia. Motilal Banarsidass 1975.
  12. Faa G, Fanos V, Giordano A. Past and future of stem cells: from Prometheus to regenerative medicine. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) 2016;5(2). doi:10.7363/050234.
  13. Schiappa J, Van Hee R. From ants to staples: history and ideas concerning suturing techniques. Acta Chir Belg.2012;112(5):395–402. doi:10.1080/00015458.2012.11680861.
  14. Nerlich AG, Zink A, Szeimies U, et al. Ancient Egyptian prosthesis of the big toe. Lancet 356(9248):2176–2179. doi:10.1016/S0140-6736(00)03507-8.
  15. Ménard S. An unknown renaissance portrait of Tagliacozzi (1545–1599), the founder of plastic surgery. Plast Reconstr Surg Glob Open 2019;7(1):e2006. doi:10.1097/ GOX.0000000000002006.
  16. Crubézy E, Murail P, Girard L, et al. False teeth of the Roman world. Nature. 1998;391(6662):29. doi:10.1038/34067.
  17. Becker A, McCulloch E, Till J. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963;197:452–454. doi:10.1038/197452a0.
  18. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975;6(3):331–343. doi:10.1016/s0092-8674(75)80001-8.
  19. Green H, Kehinde O, Thomas J. Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci U S A 1979;76(11):5665– 5668. doi:10.1073/pnas.76.11.5665.
  20. Yannas IV, Burke JF. Design of an artificial skin. I. Basic design principles. J Biomed Mater Res. 1980;14(1):65–81. doi:10.1002/jbm.820140108.
  21. Nerem RM. Tissue engineering in the USA. Med Biol Eng Comput. 1992;30(4):CE8vCE12. doi:10.1007/BF02446171.
  22. Langer R, Vacanti JP. Tissue engineering. Science 1993;260(5110):920–926. doi:10.1126/science.8493529.
  23. Colazo JM, Evans BC, Farinas AF, et al. Applied bioengineering in tissue reconstruction, replacement, and regeneration. Tissue Eng Part B Rev. 2019;25(4):259–290. doi:10.1089/ten.TEB.2018.0325.
  24. Shevchenko RV, James SL, James SE. A review of tissue-engineered skin bioconstructs available for skin reconstruction. J R Soc Interface 2010;7(43):229–258. doi:10.1098/rsif.2009.0403.
  25. Chua AW, Khoo YC, Tan BK, et al. Skin tissue engineering advances in severe burns: review and therapeutic applications. Burns Trauma 2016;4:3. doi:10.1186/ s41038-016-0027-y.
  26. Sheikholeslam M, Wright MEE, Jeschke MG, et al. Biomaterials for skin substitutes. Adv Health Mater. 2018;7(5):10.1002/ adhm.201700897. doi:10.1002/adhm. 201700897.
  27. Zeng Q, Macri LK, Prasad A, et al. Skin tissue engineering. ScienceDirect 2011. doi:10.1016/B978-0-08-055294-1. 00186-0.
  28. Vig K, Chaudhari A, Tripathi S, et al. Advances in skin regeneration using tissue engineering. Int J Mol Sci. 2017;18(4):789. doi:10.3390/ijms18040789.
  29. Vyas KS, Vasconez HC. Wound healing: Biologics, skin substitutes, biomembranes and scaffolds. Healthcare (Basel). 2014;2(3): 356–400. doi:10.3390/healthcare2030356.
  30. Lee KH. Tissue-engineered human living skin substitutes: development and clinical application. Yonsei Med J. 2000;41(6):774–779.  doi:10.3349/ymj.2000.41.6.774.
  31. Hill DM, Hickerson WL, Carter JE. A risk-benefit review of currently used dermal substitutes for burn wounds. J Burn Care Res. 2023;44(Supplement_1):S26–S32. doi: 10.1093/jbcr/irac131.
  32. Shahrokhi S, Arno A, Jeschke MG. The use of dermal substitutes in burn surgery: acute phase. Wound Repair Regen. 2014;22(1):14–22. doi:10.1111/wrr.12119.
  33. van Zuijlen P, Gardien K, Jaspers M, et al. Tissue engineering in burn scar reconstruction. Burns Trauma 2015;3:18. doi:10.1186/s41038-015-0017-5.
  34. Chang DK, Louis MR, Gimenez A, et al. The basics of Integra dermal regeneration template and its expanding clinical applications. Semin Plast Surg. 2019;33(3):185–189. doi:10.1055/s-0039-1693401.
  35. Chua AW, Khoo YC, Tan BK, et al. Skin tissue engineering advances in severe burns: review and therapeutic applications. Burns Trauma 2016;4:3. doi:10.1186/ s41038-016-0027-y.
  36. Kohlhauser M, Luze H, Nischwitz SP, et al. Historical evolution of skin grafting – a journey through time. Medicina (Kaunas) 2021;57(4):348. doi:10.3390/medicina57040348.
  1. Nguyen DQ, Potokar TS, Price P. An objective long-term evaluation of Integra (a dermal skin substitute) and split thickness skin grafts, in acute burns and reconstructive surgery. Burns 2010;36(1):23–28.  doi:10.1016/j.burns.2009.07.011.
  2. Halim AS, Khoo TL, Mohd Yussof SJ. Biologic and synthetic skin substitutes: An overview. Indian J Plast Surg. 2010;43(Suppl):S23– S28. doi:10.4103/ 0970-0358.70712.
  3. Min JH, Yun IS, Lew DH, et al. The use of matriderm and autologous skin graft in the treatment of full thickness skin defects. Arch Plast Surg. 2014; 41(4):330–336. doi:10.5999/aps.2014.41.4.330.
  4. Schneider J, Biedermann T, Widmer D, et al. Matriderm versus Integra: a comparative experimental study. Burns 2009;35(1):51–57.  doi:10.1016/j.burns.2008.07.018.
  5. Agarwal C, Kumar BT, Mehta DS. An acellular dermal matrix allograft (Alloderm®) for increasing keratinized attached gingiva: A case series. J Indian Soc Periodontol. 2015;19(2):216–220. doi:10.4103/ 0972-124X.149938.
  6. Deneve JL, Turaga KK, Marzban SS, et al. Single-institution outcome experience using AlloDerm® as temporary coverage or definitive reconstruction for cutaneous and soft tissue malignancy defects. Am Surg. 2013;79(5):476–482. doi:10.1177/000313481307900522.
  7. Hart CE, Loewen-Rodriguez A, Lessem J. Dermagraft: Use in the treatment of chronic wounds. Adv Wound Care (New Rochelle). 2012;1(3):138–141. doi:10.1089/wound.2011.0282.
  8. Purdue GF, Hunt JL, Still JM Jr, et al. A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds. J Burn Care Rehabil. 1997;18(1 Pt 1):52–57. doi:10.1097/00004630-199701000-00009.
  9. Domaszewska-Szostek AP, Krzyżanowska MO, Czarnecka AM, et al. Local treatment of burns with cell-based therapies tested in clinical studies. J Clin Med. 2021;10(3):396. doi:10.3390/ jcm10030396.
  10. Bay C, Chizmar Z, Reece EM, et al. Comparison of skin substitutes for acute and chronic wound management. Semin Plast Surg. 2021;35(3):171–180. doi:10.1055/s-0041-1731463.
  11. Brown-Etris M, Milne CT, Hodde JP. An extracellular matrix graft (Oasis® wound matrix) for treating full-thickness pressure ulcers: A randomized clinical trial. J Tissue Viability 2019;28(1):21–26. doi:10.1016/j.jtv.2018.11.001.
  12. De Decker I, Hoeksema H, Verbelen J, et al. A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial. Burns & Trauma 2023;11. doi:10.1093/burnst/ tkad015.
  13. Troy J, Karlnoski R, Downes K, et al. The use of EZ derm® in partial-thickness burns: An institutional review of 157 patients. Eplasty. 2013;13:e14.

MUDr. Julia Bartková, MBA
Klinika popáleninové medicíny, 3. LFUK
Fakultní nemocnice Královské Vinohrady
e-mail: bartkovaj@yahoo.com
ORCID: 0000-0002-0377-8155

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