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proLékaře.cz / Journals / Perspectives in Surgery / 2024 - 4

Pancreatic cancer – systemic treatment

Czech version

Authors: M. Liberko 1,2
Authors‘ workplace: Onkologická klinika Fakultní nemocnice Královské Vinohrady, Praha, Česká republika 1;  3. lékařská fakulta Univerzity Karlovy, Praha, Česká republika 2
Published in: Rozhl. Chir., 2024, roč. 103, č. 4, s. 110-116.
Category: Review
doi: https://doi.org/10.33699/PIS.2024.103.4.110–116

Overview

Pancreatic cancer is a disease with the worst long-term survival across all stages. In clinical practice, due to asymptomatic or non-specific signs and symptoms we diagnose patients mainly with locally advanced and metastatic disease, where median survival is approximately one year. However, cases of an early local recurrence or distant metastases are observed even in early stages after curative surgery, and long-term survival is an exception even in these early stages of the disease. Despite these adverse characteristics, an improvement in median overall survival has been observed also in patients with pancreatic cancer, particularly in the last few years. It is due to advancements in the diagnosis, surgery, but mainly due to improvements in cancer treatment (chemotherapy – adjuvant, neoadjuvant, perioperative, induction and palliative, and radiotherapy). The results of many studies across all stages (resectable, borderline resectable, locally advanced, metastatic) have been published, showing an improved survival. The aim of this article is to provide a review of current treatment options for pancreatic ductal adenocarcinoma.

Keywords:

Chemotherapy – radiotherapy – resectable pancreatic cancer – borderline resectable pancreatic cancer – locally advanced pancreatic cancer – metastatic pancreatic cancer

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MUDr. Marián Liberko
Onkologická klinika FNKV a 3. LF UK
Šrobárova 1 150/50,
100 34 Praha 10
e-mail: marian.liberko@fnkv.cz
ORCID: 0000-0001-8338-1555

Labels
Surgery Orthopaedics Trauma surgery
Ductal adenocarcinoma of the pancreas, a significant advance in treatment?
Imaging methods in the diagnosis and treatment of pancreatic cancer
Minimal invasive surgery of pancreatic cancer at the Department of Surgery of Masaryk university hospital Brno, Czech Republic
Pancreatic surgery at the University Hospital Kralovske Vinohrady: 10-year review with a survival analysis for pancreatic ductal adenocarcinoma
Meckel‘s diverticulum as a cause of gastrointestinal bleeding in an adolescent patient
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Perspectives in Surgery

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