Extraesophageal Reflux (Part 2) ORL Manifestation and Therapy
Authors:
Karol Zeleník 1; Pavel Komínek 1; I. Stárek 2; E. Machytka 3
Authors‘ workplace:
Otorinolaryngologická klinika FN Ostrava
; přednosta doc. MUDr. P. Komínek, PhD., MBA
Otorinolaryngologická klinika LF UP a FN, Olomouc
1; přednosta prof. MUDr. I. Stárek, CSc.
Interní klinika FN Ostrava
2; přednosta doc. MUDr. A. Martínek, CSc.
3
Published in:
Otorinolaryngol Foniatr, 57, 2008, No. 3, pp. 151-158.
Category:
Comprehensive Reports
Overview
Extraesophageal reflux (EER) has been implicated in the pathogenesis of several otolaryngological disorders, including posterior laryngitis, vocald fold nodules, paroxysmal laryngospasm, Reinke’s edema, vocal folds ulcers and granuloma, globus pharyngeus, subglotic and laryngotracheal stenosis, chronic rhinosinusitis, chronic ear complaints, snoring and laryngopharyngeal carcinoma. These patients, due to different pathophysiology, usually do not suffer from the typical symptoms of gastroesophageal reflux disease, such as heartburn, regurgitation or esophagitis. Gastroesophageal reflux disease and EER are two independent clinical entities and can be present simultaneously as well as fully independently from each other. We should consider EER in all patients with reccurent or chronic inflammation, which do not respond to standard treatment. Diagnosis is usually done by 24hour pH–metry with proximal sensor placed above the level of upper esophageal sphincter. Best treatment outcomes are achieved with twice daily proton pump inhibitors therapy.
Key words:
gastroesophageal reflux, extraesophageal reflux, otolaryngologic manifestation, reflux symptom index, reflux finding score.
Sources
1. Anandasabapathy, S., Jaffin, B. W.: Multichannel intraluminal impedance in the evaluation of patients with persisistent globus on proton pump inhibitor terapy. The Annals of Otology, Rhinology & Laryngology, 115, 2006, 8, s. 563-570.
2. Aviv, E. J., Liu, H., Parides, M. et al.: Laryngopharyngeal sensory deficits in patients with laryngopharyngeal reflux and dysphagia. Ann. Otol. Rhinol. Laryngál., 109, 2000, s. 1000-1006.
3. Axford, S. E., Sharp, N., Ross, P. E. et al.: Cell biology of laryngeal epithelial defenses in health and disease: preliminary studies. The Annals of Otology, Rhinology & Laryngology, 110, 2001, 12, s. 1099-1108.
4. Belafsky, C. P., Postma, G. N., Amin, R. M., Koufman J. M.: Symptoms and findings of laryngopharyngeal reflux. Ear, Nose & Throat Journal, 81, 2002, 9, s. 10-13.
5. Belafsky, C. P., Postma, G. N., Koufman J. M.: The validity and reliability of the reflux finding score. Laryngoscope, 111, 201, s. 1313-1317.
6. Cherry, J., Margulies, S. I.: Contact ulcers of the larynx. Laryngoscope, 78, 1968, s. 1937-1940.
7. Cook, I. J.: Clinical disorders of the upper esophageal sphincter. GI Motility online [online]. c2006, [cit. 2008-02-11]. Dostupné z <http://www.nature.com/gimo/contents/-/pt1/full/gimo37.html> .
8. Crapko, M., Kerschner, J. E., Syring, M., Johnston, N.: Role of extra-esophageal reflux in chronic otitis media with effusion. Laryngoscope, 117, 2007, s. 1419-1423.
9. DelGaudio, J. M.: Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope, 115, 2005, s. 946-957.
10. Gray, S., Miller, R., Meyer, C. M. et al.: Adjunctive measures for successful laryngotracheal reconstruction. Ann. Otol. Rhinol. Laryngál., 96, 1987, s. 509-513.
11. Halstead, L. A.: Gastroesophageal reflux: a critical factor in pediatric subglotic stenosis. Otolaryngol Head Neck Surg., 120, 1999, s. 683-688.
12. Hickson, Ch., Simpson, C. B., Falcon, R.: Laryngeal pseudosulcus as a predictor of laryngopharyngeal reflux. Laryngoscope, 111, 2001, s. 1742-1745.
13. Jecker, P., Orloff, L. A., Mann, W. J.: Extraesophageal reflux and upper aerodigestive tract diseases. ORL, 67, 2005, s. 185-191.
14. Johnston, N., Bulmer, D., Gill, G. A. et al.: Cell biology of laryngeal epithelial defenses in health and disease: further studies. The Annals of Otology, Rhinology & Laryngology, 112, 2003, 6, s. 481-491.
15. Johnston, N., Dettmar, P. W., Bishwokarma, B. et al.: Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope, 117, 2007, s. 1036-1039.
16. Johnston, N., Dettmar, P. W., Lively, M. O. et al.: Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. The Annals of Otology, Rhinology & Laryngology, 115, 2006, 1, s. 47-58.
17. Johnson, N., Knight, J., Dettmar, P. W. et al.: Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope, 114, 2004, s. 2129-2134.
18. Keles, B., Öztürk, K., Günel, E. et al.: Pharyngeal refluxin children with chronic otitis media with effusion. Acta Otolaryngol, 124, 2004, s. 1178-1181.
19. Klinkenberg-Knol, E. C.: Otolaryngologic manifestations of gastro-oesophageal reflux disease. Scand. J. Gastroenterol, 33, 1998, Suppl. 225, s. 24-28.
20. Koufman J. A.: Laryngopharyngeal reflux 2002: A new paradigm of airway disease. Ear, Nose & Throat Journal, 81, 2002, 9, s. 2-6.
21. Koufman J. A.: Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear, Nose & Throat Journal, 81, 2002, 9, s. 7-9.
22. Lewin, J. S., Gillenwater, A. M., Garrett, J. D. et al.: Characterization of laryngopharyngeal reflux in patients with premalignant or early carcinomas of the larynx. Cancer, 97, 2003, s. 1010-1014.
23. Little, F. B., Koufman, J. A., Kohut, R. I. et al.: Effect of gastric acid on the pathogenesis of subglotic stenosis. Ann.Otol. Rhinol. Laryngál., 94, 1985, s. 516-519.
24. Lukáš, K. a kol.: Refluxní choroba jícnu. Druhé vydání. Nakladatelství Karolinum, Praha, 2003, 209 s.
25. Lukáš, K., Mareček, P.: Etiopatogeneze refluxní choroby jícnu. Časopis lékařů českých, 139, 2000, 15, s. 455-459.
26. Mamede, R. C. M., De Mello-Filho, F. V., Vigário, C. L. et al.: Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. Otolaryngol Head Neck Surg., 122, 2000, s. 607-610.
27. McMurray, S. J., Gerber, M., Stern, Y. et al.: Role of Laryngoscopy, dual pH probe monitoring, and laryngeal mucosal biopsy in the diagnosis of pharyngolaryngeal reflux. The Annals of Otology, Rhinology & Laryngology, 110, 2001, 4, s. 299-304.
28. Milstein, C. F., Charbel, S., Hicks, D. M. et al.: Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope). Laryngoscope, 115, 2005, s. 2256-2261.
29. Morinaka, S., Ichimiya, M., Nakamura, H.: Detection of Helicobacter pylori in nasal and maxilary sinus specimen from patients with chronic sinusitis. Laryngoscope, 113, 2003, 113, s. 1557–1663.
30. Ozdek, A., Cirak, M. Y., Samin, E. et al.: A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report. Laryngoscope, 113, 2003, s. 679-682.
31. Payne, R. J., Kost, K. M., Frenkiel, S. et al. Laryngeal inflammtion assessed using the reflux finding score in obstructive sleep apnea. Otolaryngol Head Neck Surg., 134, 2006, s. 836-842.
32. Phipps, C. D., Wood, W. E., Gibson, W. S. et al.: Gastroesophageal reflux contributing to chronic sinus disease in children. Arch Otolaryngol Head Neck Surg., 126, 2000, s. 831-836.
33. Pincus, R. L., Kim, H. H., Silvers, S. et al.: A study of the link between gastric reflux and chronic sinusitis in adults. Ear, Nose & Throat Journal, 85, 2006, 3, s. 174-178.
34. Poelmans, J., Tack, J., Feenstra, L.: Prospective study on the incidence of chronic ear comlaints related to gastroesophageal reflux and on the outcome of atireflux therapy. The Annals of Otology, Rhinology & Laryngology, 111, 2002, s. 933-938.
35. Postma, G. N.: Ambulatory pH monitoring methodology. The Annals of Otology, Rhinology & Laryngology, 109, 2000, 10, s. 10-14.
36. Postma, G. N., Belafsky, P. C., Aviv, J. E., Koufman J. A.: Laryngopharyngeal reflux testing. Ear, Nose & Throat Journal, 81, 2002, 9, s. 14-18.
37. Postma, G. N., Johnson, J. F., Koufman J. A.: Treatment of laryngopharyngeal reflux. Ear, Nose & Throat Journal, 81, 2002, 9, s. 24-26.
38. Postma, G. N., Tomek, M. S., Belafsky, P. C., Koufman, J. A.: Esophageal motor function in laryngopharyngeal reflux is superior to that in classic gastroesophageal reflux disease. The Annals of Otology, Rhinology & Laryngology, 110, 2001, 12, s. 1116-1116.
39. Richter, J. E.: Review article: extraesophageal manifestation of gastro-oesophageal reflux disease. Aliment Pharmacol Ther, 22, 2005, (Suppl. 1), s. 70-80.
40. Rožmanic, V., Velepic, M., Ahel, V. et al.: Prolonged esophagealpH monitoring in the evaluation of gastroesophageal reflux in childrenwith chronic tubotympanal disorders. Journal of Pediatric Gastroenterology and Nutrition, 34, 2002, s. 278-280.
41. Sataloff, R. T., Castell, D. O., Katz, P. O., Sataloff, D. M.: Reflux laryngitis and related disorders. Third edition. Plural Publishing, 2006, 171 s.
42. Shay, S. S., Johnson, L. F., Richter, J. E.: Acid rereflux: A review, emphasizing detection by impedance, manometry, and scintigraphy, and the immpact on acid clearing pathofysiology as well as interpreting the pH record. Digestive Diseases and Sciences, 48, 2003, s. 1-9.
43. Siupsinskiene, N., Adamonis, K, Toolhil, R. J. et al.: Quality of life in laryngopharyngeal reflux patient. Laryngoscope, 117, 2007, s. 480-484.
44. Smit, C. F., van Leeuwen, J. M. A., Mathus-Vliegen L. H. M. et al.: Gastropharyngeal and gastroesophageal reflux in globus an hoarseness. Arch. Otolaryngol Head Neck Surg., 126, 2000, s. 827-830.
45. Suskind, D. L., Thomson, D. M., Gulati, M. et al.: Improved infant swallowing after gastroesophageal reflux disease treatment: a function of improved laryngeal sensation? Laryngoscope, 116, 2006, s. 1397-1403.
46. Tasker, A., Dettmar, P. W., Panetti, M. et al.: Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope, 112, 2002, s. 1930-1934.
47. Velepic, M. M., Velepic, S. M., Starcevic, R. et al.: Gastroesophageal reflux and sequelae of chronic tubotympanal disorders in children. Acta Otolaryngol, 124, 2004, s. 914-917.
48. Vincent, D. A., Garrett, J. D., Radionof, S. L. et al.: The proximal probe in esophageal pH monitoring: development of a normaive database. J. Voice, 14, 2000, s. 247-254.
49. Walner, D. L., Stern, Y., Gerber, M. E. et al.: Gastroesophageal reflux in patient with subglotic stenosis. Arch. Otolaryngol Head Neck Surg., 124, 1998, s. 551-555.
50. Wise, S. K., Wise, J. C., DelGaudio, J. M.: Gastroesophageal reflux and laryngopharyngeal reflux in patients with sleep-disordered breathing. Otolaryngol Head Neck Surg., 135, 2006, s. 253-257.
51. Ylitalo, R., Baugh, A., Li, W., Thibeault, S.: Effect of acid and pepsin on gene expression in laryngeal fibroblasts. The Annals of Otology, Rhinology & Laryngology, 113, 2004, 11, s. 866-871.
52. Ylitalo, R., Thibeault, S. L.: Relationship between time of exposure of laryngopharyngeal reflux and gene expression in laryngeal fibroblast. The Annals of Otology, Rhinology & Laryngology, 115, 2006, 10, s. 775-778.
53. Zalzal, G. H., Choi, S. S., Patel, K. M.: The effect of gastroesophageal reflux on laryngotracheal reconstruction. Arch Otolaryngol Head Neck Surg., 122, 1996, s. 297-300.
54. Loveček, M., Maňásková, E.: Možnosti 24hodinové pH-metrie horního jícnu v diagnostice ezofagofaryngeálního refluxu. Otorinolaryng. a Foniat. /Prague/, 55, 2006, č. 4, s. 193-198.
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2008 Issue 3
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