Clinical Problems of Hypopharygeal Carcinomas
Authors:
L. Černý; M. Eber; R. Černý
Authors‘ workplace:
ORL oddělení nemocnice Karviná-Ráj
primář MUDr. M. Eber
Published in:
Otorinolaryngol Foniatr, 56, 2007, No. 3, pp. 165-172.
Category:
Comprehensive Reports
Overview
The authors refer comprehensively and systematically to clinical manifestations, diagnostic approaches and effects of therapeutic modalities in view of prognosis of hypopharyngeal carcinomas. Three case reports exemplify their experience with surgical treatment of the disease.
The first patient suffered from carcinoma of the piriform sinus infiltrating the left pharyngeal wall.. It was removed within the framework of TLE and partial PHE. Enlarged cervical nodes removed during bilateral block dissections were bilaterally affected by metastases. After almost two year time lapse the patient died due to bronchopneumonia. No signs of malignoma activation were evident.
The same kind of tumor in the second patient having originated in the left lateral pharyngeal wall was removed during lateral pharyngotomy. The patient happily survives two years without signs of tumor activation in a good health state.
The third patient also suffered from an extended size of carcinoma of the left lateral pharyngeal wall and larynx with adjacent portion of hypopharynx has to be sacrificed. Metastases were discovered only ipsilaterally similar to the previous patient. The patient survives five years after the surgery in a good health state.
The communication is intended to address a broader professional public. It draws attention to serious prognosis of this kind of malignoma at the fork of respiratory and alimentary pathways. It is caused by unmanageable metastases of the disease in regional and distant lymphatic nodes. The expectations of the affected patients lay in the area of sentinel nodes. If the positive radioactive nodes are removed in time there is a real chance to improve the prognosis of in HPC categories, especially those classified as T3N1 with the exception of T4N2-3. The following development of the method hopefully shows, whether the expectations are not undue.
Key words:
hypopharyngeal carcinomas, metastases, prognosis.
Sources
1. Alex, J. C.: The aplication of sentinel node radiolocation of solid tumors of the head and neck. Laryngoscope, 114, 2004, s. 2-19.
2. Aluffi, P., Policarpo, M., Pia, F.: Contralateral cervical lymph node metastases in piriform sinus carcinoma. Otolaryngolog-head and neck surg., 134, 2006, s. 650-653.
3. Černý, L., Müllerová, M.: Otolaryngologie severomoravské oblasti v číslech. Choroby hlavy a krku, 1992, 3-4, s. 45-48.
4. Dumich, P. S., Bruce, W., Pearson, M. D., Weiland, L.: Suitability of near-total laryngophangectomy in the sinus poriform carcinoma. Arch. Otolaryngol., 110, 1987, s. 664-669.
5. Ganzer, U., Meyer-Breiting, E.: Zur Behandlung des Hypopharynx-Karzinoma. Laryng-Rhino-Otol., 53, 1982, s. 643-645.
6. Hannemann, R.: Paliative Chemotherapie von Kopf-Hals-Tumoren. Lyryng-Rhino-Otol., 85, 2006, s. 172-178.
7. Ho Kim, Y., Koob. Chang Lim, Y., , J. S., Heo Kim, S., Choi, E. C.: Lymphatic metastatis to level II b in hypopharyngeal squamous cell carcinoma. Arch. Otolaryngol. Head and Neck Surg., 132, 2006, s. 1060-1064.
8. Jeřábek, L., Horáček, J., Hybášek, I.: Analýza histopatologických nálezů resekátů hrtanu. Otorinolaryng. a Foniat. /Prague/, 53, 2004, s. 147-150.
9. Keller, A. Z., Tetros, M.: The assotiation of alcohol and tabacco with mouth and pharynx cancer. Cancer J. Amer., 55, 1965, s. 1578-1584.
10. Konečný, M., Hladký, R., Rošová, O.: Rakovina hypofaryngu v Onkologickém ústavu a ORL klinice MU v Brně. Čs. otolaryng., 24, 1975, s. 327-321.
11. Kleinsasser, O.: Zur Behandlung der Karzinome des Sinus piriformis. HNO, 37, 1989, s. 460-464.
12. Kleinsasser, O.: Tumoren des Larynx und Hypopha-rynx. G. Thieme Veerl., Stuttgart-New York, 1987, s. 373
13. Leyland, M. K., Sessions, D. G., Lehox, J.: The influence of lymph node metastatis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, pharynx and hypopharynx, N0 versus N+. Laryngoscope, 115, 2005, s. 629-639.
14. Lorane, J., Back, L., Koivunen, O., Grenman, R.: Hypopharyngeal carcinoma in Finland from 1990-99. Eur. Arch. Otorhinolaryngol., 262, 2005, s. 374-378.
15. Lufkin, R. B., Hanafee, W. N., Wirtham, D., Hoover, L.: Larynx and hypopharynx: MR imaging with surface coils. Radiology, 158, 1986, s. 757-754.
16. Meyer-Breiting, E., Rettinger, R., Czerny, R.: Zur T-Klassifikation des Hypopharynxkarzinoms. Eur. Arch. Oto-Rhino-Laryngol., 151, 1993/II, s. 167-169.
17. Mrzena, L., Betka, J., Plzák, J., Stárek, I., Kodetová, D.: Peroperační identifikace a bioptické vyšetření sentinelové uzliny u nádorů hlavy a krku. Otorinolaryng. a Foniat. /Prague/, 2005, 3, s. 119-127.
18. Muir, C., Weiland, L.: Upper serodigestiv tract cancer. Cancer Suppl., 75, 1995, s. 147-150.
19. Muto, M., Nakane, M., Kadata, M., Sano, Y., Yshida, S.: Squamous cell carcinoma in situ at laryngeal and hypopharyngeal mucosal sites. Cancer, 101, 2004, s. 1375-1381.
20. Queslati, Z., Zaglaoui, I., Touati, S., Gritli, S., Mokni, B.: Concomitant failure of hypopharyngeal squamous cell carcinoma. Cancer Radiother., 8, 2004, s. 352-357.
21. Praženica, P., Lacman, J., Holý, R., Navara, M., Voldřich, Z.: Uzlinové krční metastázy spinocelulárního karcinomu orofaryngu a hrtanu (1. a 2. část). Otorinolaryng. a Foniat. /Prague/, 55, 2006, s. 130-112.
22. Richey, L. M., Shores, C. G., George, J., Lee, S., Couch, M. J., Sutton, D. K., Weissler, C.: The Effectivenes of salvage surgery the failire of primary concomitant chemoradiation in head and neck cancer. Otolaryngol.-Head and Neck Surg., 136, 2007, s. 98-103.
23. Rodmond, K. P.: Recurrent advanced (T3 T4) head and neck squamous cell carcinoma. Otolaryngol.-Head and Neck Surg., 130, 2004, s. 35-38.
24. Ross, G. L.: The first international confernce on sentinel node biopsy in mucosal head and neck cancer and adoption of multicenter trial protocol. Ann. Surg. Oncol., 9, 2002, s. 406-409.
25. Sesterhenn, A. M.: Therapie von Kopf-Hals-Karzinomen im fortgeschrittenen Lebensalter. Laryngo-Rhono-Otol., 86, 2007, s. 95-100.
26. Sewnaik, A., Hoorweg, J. J., Knegt, P. P., Woeringa, M. H., Kerrebinj, J. D.: Treatment of hypopharyngeal carcinoma analysis of national-wide study in the Netherland over a 10-years period. Clin. Otolaryngol., 30, 2005; 52-57
27. Silverman, P., Bosen, E. H., Fischer, S. R., Cole, T. B., Halvorsen, R. A.: Carcinoma of the larynx and hypopharynx. Radiology, 151, 1984, s. 697-702.
28. Smilek, P., Kostřica, R., Dušek, L., Veselý, K., Rottenberg, J.: Kvalita života nemocných rakovinou hlavy a krku po rozsáhlých chirurgických výkonech. Otorinolaryng. a Foniat. /Prague/, 53, 2004, s. 224-228.
29. Stárek, I., Koranda, P., Mrzena, L., Betka, J., Kučerová, I.: Biopsie sentinelových uzlin u nádorů hlavy a krku. Otorinolaryng. a Foniat. /Prague/, 55, 2006, s. 150-160.
30. Starý, J.: Léčba karcinomů hypofaryngu v Jihočeském kraji v letech 1961-1980. Čs. otolaryngol., 36, 1987, s. 273-280.
31. Teymoortash, A., Wulf, H., Werner, J. A.: Chirurgie von Karzinomen der obern Luft-und Speisewege bei Patienten im fortgeschrittenen Lebensalter. Laryngo-Rhino-Otol., 81, 2002, s. 293-298.
32. Wenzel, S., Sagowski, C., Kehrl, W., Aksima, T., Metternich, F. U.: Kapselruptur metastatich befallener Lymphknoten als entcheidendes Kriterium bei Karzinomen der oberen aerodigestiv-Traktes-Hamburger Erfahrungen. Laryngo-Rhino-Otol., 82, 2003, s. 707-712.
33. Wolfensberger, M., Kikinis, R., Schmidt, S., Wichmarin, W.: Der Beitrag der Computertomographie zur Klassifikation on von Hypopharynx und Larynxkarzinomen. Laryngo-Rhino-Otol., 66, 1982, s. 84-87.
Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)Article was published in
Otorhinolaryngology and Phoniatrics
2007 Issue 3
Most read in this issue
- Clinical Problems of Hypopharygeal Carcinomas
- Stenoses of Trachea after Cannulation
- Profiloplasty of Rhinoplasty
- Using Cartilage Grafts by Retraktion Pockets by Children