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Examination of Exposure to Genotoxic Chemicals in a Printing Plant, Part II: Rotogravure Inks and the Ames Test


Authors: Pelclová Daniela 1;  Černá Milena 2;  Pastorková Anna 2;  Dlasková Zdenka 1;  Procházka Bohumír 2
Authors‘ workplace: Klinika nemocí z povolání 1. LF UK, přednosta doc. MUDr. Daniela Pelclová, CSc. 2 Státní zdravotní ústav, Praha, ředitel doc. MUDr. Jaroslav Kříž 1
Published in: Pracov. Lék., , 1999, No. 3, s. 103-106.
Category:

Overview

Repeated findings of increased percentage of chromosomal aberrations in the peripheral blood lymphocytes of printers engagedwith rotogravure printing resulted in investigation of possible relationship with exposure to rotogravure inks. None of the basicshades of rotogravure inks exhibited mutagenic activity in the Ames test. Examination of urine in the 19 exposed printers anda control group of 22 subjects of the same locality did not show significant mutagenic activity. It became obvious that the Ames testdid not show any role of rotogravure inks in the increased exposure to genotoxic chemicals in the printers, who were simultaneous-ly exposed to toluene. Hippuric acid did not exhibit mutagenic activity at concentrations of 10 mg to 15 mg per plate. The resultssupport the hypothesis of genotoxic effects of toluene.

Key words:
rotogravure printing, rotogravure inks, toluene, Ames test, genotoxicity

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Labels
Hygiene and epidemiology Hyperbaric medicine Occupational medicine
Topics Journals
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