Antiepileptické léky a lékové interakce: klinická kazuistika
Authors:
Hundie Tesfaye 1; E. Eva Klapková 1; Alena Tesfayeová 2; Vladimír Komárek 2
Authors‘ workplace:
Department of Clinical Biochemistry and Pathobiochemistry, Division of Clinical Pharmacology, University Hospital, Motol, nd Faculty of Medicine, Charles University, Prague, Czech Republic
1; Department of Paediatric Neurology, University Hospital, Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
2
Published in:
Čas. Lék. čes. 2011; 150: 451-456
Category:
Case Report
Overview
Epilepsie je závažné onemocnění postihující dětskou i dospělou část populace po celém světě. Vzhledem k btížnému zjišťování etiologie je prvotní nastavení léčebných postupů často řízené empirickými terapeutickými úvahami. Zvládnutí projevů vyžaduje použití antiepileptických léčiv, přičemž mnoho z ich vykazuje možné lékové interakce. Speciálně děti jsou vnímavé k ékovým interakcím a často vykazují atypické nežádoucí projevy vyžadující speciální péči.
Cíl.
Popis případu patnáctileté dívky trpící refrakterní epilepsií na podkladě fokální kortikální dysplazie, u níž bylo zhoršování klinického stavu s elkou pravděpodobností spojováno s ékovými interakcemi mezi běžně předepisovanými antiepileptiky, jmenovitě kyselinou valproovou, fenobarbitalem, nebo primidonem a karbamazepinem.
Klíčová slova:
fokální kortikální dysplazie, léky na refrakterní epilepsii, léková interakce.
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