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The Risk of Malignancy After Organ Transplantation


Authors: R. Gürlich 1,2;  J. Novotný 3;  I. Stříž 4;  E. Honsová 5;  M. Oliverius 1;  L. Janoušek 1;  E. Pokorná 6;  P. Maruna 7
Authors‘ workplace: Klinika transplantační chirurgie IKEM, Praha 1;  I. chirurgická klinika 1. LF UK a VFN, Praha 2;  Onkologická klinika 1. LF UK a VFN, Praha 3;  Oddělení klinické imunologie1. LF UK a VFN, Praha 4;  Pracoviště klinické a transplantační patologie1. LF UK a VFN, Praha 5;  Transplantcentrum IKEM, Praha 6;  Ústav patologické fyziologie 1. LF UK, Praha 7
Published in: Čas. Lék. čes. 2005; 144: 597-600
Category: Review Article

Overview

Improvements in immunosuppressive therapy during the past decade brought about improvements of the long term tolerance of organ allografts. However, the long-term immunosuppressive therapy has an important limitation, because it can increase the risk of cardivascular diseases, infections and tumors. As compared with age-matched healthy population, organ-transplant recipients have an increased incidence of tumors. 

Key words:
immunosuppression, tumor, transplantation.


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