The Influence of Fibrates on the Composition of VLDL and LDL Lipoproteinsand Their Oxidation Parameters in Hypertriglyceridemia

Overview

Background.
Meta-analyses of epidemiological studies proved that hypertriacylglycerolemia (HTAG) is anindependent CHD risk factor. The VLDL lipoproteins, which are the main TAG carrier, are precursors of atherogenicLDL and their increased concentration is related to the decrease of antiatherogenic HDL, increased ratio of small,dense LDL and represents one of the causes of the endothelial dysfunction. According to some authors, HTAG isone of the factors of the oxidation stress.Material and Methods. 45 patients of the studied group received 200 mg of micronised fenofibrate per day forsix weeks. Before the beginning and after the end of treatment, following examinations were carried out: concentrationof plasma lipids, lipoproteins, and apolipoproteins, composition of fatty acids (FA) in main lipid plasma classes andLDL (phosphatidylcholine – PC, TAG, cholesteryl esters – CE) and lipoperoxidation in VLDL and LDL, isolatedby preparative ultracentrifugation.Results and Conclusions. In plasma, the treatment of HTAG led to a significant decrease of TC, TAG and apo-Bconcentration and to the increase of cholesterol concentration in HDL and in both HDL 2 and HDL 3 subfractions. Inisolated LDL particles we observed a decrease of the TAG portion (by 25 %) together with significant lag phaseprolongation (by 33 %, P

Key words:
HTAG, VLDL and LDL composition, VLDL and LDL lipoperoxidation, composition of fatty acids,phenofibrate.