Evaluation of Antibiotic Consumption Dynamics and Development ofResistance in Selected Bacterial Pathogens

Overview

Background.
Evaluation of antibiotic consumption and the surveillance of bacterial pathogens resistance appearsto be an indispensable part of antibiotic policy. The aim of this study was to evaluate dynamics of antibioticsconsumption and resistance development in selected bacterial strains (Pseudomonas aueruginosa, Staphylococcusaureus and Staphylococcus epidermidis) in the environment of Faculty Hospital.Methods and Results. The analysis was focused on the development of antibiotic consumption and monitoringof the development of bacterial resistance. Samples were taken in internal and surgical departments of GeneralFaculty Hospital in Prague in 1992, 1995, and 1999. The evaluation of antibiotic consumption was based onAnatomical Therapeutic and Chemical classification system and the Defined Daily Doses (DDD). The consumptionin the follow up period almost doubled in surgical department while in internal medicine department was decreasedby almost one third. In both department, namely in the surgical one significant increase of bacterial resistance totested antibiotics was noted.Conclusion. The important part of the local antibiotic policy is the monitoring of development of bacterial resistanceand consumption of antibiotics.

Key words:
antibiotic consumption, bacterial resistance, antibiotic policy.