Hepatotoxicity induced by bodybuilding supplements

Czech version

Authors: Martina Jakabovičová; Zuzana Urkovičová; Tereza Hlavatá; Mária Szántová
Authors‘ workplace: III. interná klinika LF UK a UN, Nemocnica akademika Ladislava Dérera, Bratislava
Published in: Vnitř Lék 2020; 66(1): 28-33
Category:

Overview

Bodybuilding supplements are known as anabolic-androgenic steroids (AAS), as well as dietary supplements with their addition. Without medical indications, they are illegal but easily accessible and harmful, capable of causing various forms of liver damage from the transient increase in serum enzymes through acute cholestatic syndrome to the development of hepatic tumours in long-term use. The strongest hepatotoxic effects are associated with alkylated forms, although tumours have also been associated with unmodified or esterified testosterone. Since the 1980s, they have been widespread not only in top-level sport but also in the general population to improve athletic performance and body shaping. According to epidemiological studies, there has been an increase in their use in recent years. The paper provides an overview of the most common clinical forms of hepatotoxicity resulting from using AAS.

Keywords:

anabolic‑androgenic steroids – herbal and dietary supplements (HDS) – hepatocellular carcinoma – prolonged jandice – testosterone

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