Vitamin D deficiency and its health effects

Czech version

Authors: Pavel Horák
Authors‘ workplace: III. interní klinika –nefrologická, revmatologická, endokrinologická LF UP a FN Olomouc
Published in: Vnitř Lék 2019; 65(11): 724-727
Category: Actualities

Overview

Vitamin D₃ cholecalciferol is produced from its cholesterol precursors in the skin under the influence of ultraviolet calc. Its subsequent hydroxylation in the liver and kidneys leads to the formation of its most active metabolite calcitriol, which plays one of the key roles in the management of calcium phosphate metabolism. However, it also has the ability to regulate the function of a number of cells and tissues that express the vitamin D receptor. The most widespread method to evaluate the status of vitamin D in the body is to measure serum levels of its metabolite 25 hydroxyvitamin D – 25 (OH) D. Optimal values range between 75–125 nmoll / l. Its deficit is widespread in the human population worldwide and has a significant impact on the prevalence of metabolic bone diseases. Its deficiency may support the dysfunction of many other body systems. Ensuring optimal levels of vitamin D in the population is a challenge not only for health care and especially for government administration.

Keywords:

bone diseases – calciferol – calcium metabolism – deficiency – pleiotropic effect

Sources

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