Fatty pancreas disease: clinical impact
Authors:
Martin Blaho 1; Petr Dítě 1; Lumír Kunovský 2,3; Arnošt Martínek 1
Authors‘ workplace:
Gastroenterologické oddělení Interní kliniky LF OU a FN Ostrava
1; Interní gastroenterologická klinika LF MU a FN Brno, pracoviště Bohunice
2; Chirurgická klinika LF MU a FN Brno, pracoviště Bohunice
3
Published in:
Vnitř Lék 2018; 64(10): 949-952
Category:
Overview
Pancreatic steatosis is the name for a state characterized by an increased accumulation of fat in the pancreas. It is most frequently due to obesity and the metabolic syndrome, other etiological factors may include some congenital syndromes, toxic substances or viral diseases. Diagnostics is based on non-invasive imaging methods. The most accessible is abdominal ultrasound, also endoscopic ultrasound, computed tomography or magnetic resonance imaging can be used. In clinical practice, pancreatic steatosis is in particular significant because of its close association with type 2 diabetes mellitus, non-alcoholic fatty liver disease and cardiovascular diseases. The disorder may aggravate the burden of acute pancreatitis, examined is its relationship to pancreatic cancer. Significant are also surgical reports on complications after pancreatic surgeries on individuals with pancreatic steatosis.
Key words:
acute pancreatitis – dyslipidemia – fatty pancreas – non-alcoholic fatty pancreas disease – non-alcoholic steatopancreatitis – obesity – pancreatic carcinoma
Sources
- Alberti KG,Eckel RH, Grundy SM et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation 2009; 120(16): 1640–1645. Dostupné z DOI: <http://dx.doi.org/10.1161/CIRCULATIONAHA.109.192644>.
- Hůlek P, Dreslerová I. Steatóza a steatopankreatitida u diabetika. Vnitř Lék 2011; 57(4): 364–367.
- Sodhi KS,Thapa BR, Khandelwal S et al. Pancreatic lipomatosis in an infant with cystic fibrosis. Pediatr Radiol 2005; 35(11): 1157–1158. Dostupné z DOI: <http://dx.doi.org/10.1007/s00247–005–1520–9>.
- Raeder H, Haldorsen IS, Ersland L et al. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Diabetes 2007; 56(2): 444–449. Dostupné z DOI: <http://dx.doi.org/10.2337/db06–0859>.
- Mathur A, Marine M, Lu D et al. Nonalcoholic fatty pancreas disease. HPB (Oxford) 2007; 9(4) 312–318. Dostupné z DOI: <http://dx.doi.org/10.1080/13651820701504157>.
- Makay O, Kazimi M, Aydin U et al. Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy. Int J Clin Oncol 2010; 15(1): 88–92. Dostupné z DOI: <http://dx.doi.org/10.1007/s10147–009–0001–9>.
- Smits MM, Van Geenen EJ. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol 2011; 8(3): 169. Dostupné z DOI: <http://dx.doi.org/10.1038/nrgastro.2011.4>.
- Blaho M, Dítě P. Metabolic syndrome and non-alcoholic fatty pancreas disease (NAFPD). Pancreatology 2018; 18(4 Suppl): S108.
- Ambesh P, Lal H. Pancreatic lipomatosis: complete replacement of pancreas by fat. J Clin Diagn Res 2015; 9(10): OL01. Dostupné z DOI: <http://dx.doi.org/10.7860/JCDR/2015/15085.6653>.
- Wong VW, Wong GL, Yeung DK et al. Fatty pancreas, insulin resistance, and β-cell function: a population study using fat-water magnetic resonance imaging. Am J Gastroenterol 2014; 109(4): 589–597. Dostupné z DOI: <http://dx.doi.org/10.1038/ajg.2014.1>.
- Schafer JH. The normal weight of the pancreas in the adult human being: a biometric study. The Anatomical Record 1926; 32(2): 119–132. Dostupné z DOI: <https://doi.org/10.1002/ar.1090320204>.
- Ogilvie RF. The islands of Langerhans in 19 cases of obesity. J Pathol 1933; 37(3): 473–481. Dostupné z DOI: <https://doi.org/10.1002/path.1700370314>.
- Zhang X, Cui Y, Fang L et al. Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats. Pancreas 2008; 37: e31-e38. Dostupné z DOI: <http://dx.doi.org/10.1097/MPA.0b013e3181744b50>.
- Wu WC, Wang CY. Association between non-alcoholic fatty pancreatic disease (NAFPD) and the metabolic syndrome: case–control retrospective study. Cardiovasc Diabetol 2013; 12: 77. Dostupné z DOI: <http://dx.doi.org/10.1186/1475–2840–12–77>.
- Uygun A, Kadayifci A, Demirci H et al. The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis. Eur J Intern Med 2015; 26(1): 37–41. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ejim.2014.11.007>.
- Zhou J, Li ML, Zhang DD et al. The correlation between pancreatic steatosis and metabolic syndrome in a Chinese population. Pancreatology 2016; 16(4): 578–583. Dostupné z DOI: <http://dx.doi.org/10.1016/j.pan.2016.03.008>.
- Rossi AP et al. Predictors of ectopic fat accumulation in liver and pancreas in obese men and women. Obesity 2011; 19(9): 1747–1754.
- Sepe PS, Ohri A, Sanaka S et al. A prospective evaluation of fatty pancreas by using EUS. Gastrointest Endosc 2011; 73(5): 987–993. Dostupné z DOI: <http://dx.doi.org/10.1016/j.gie.2011.01.015>.
- Mirrakhimov AE. Nonalcoholic fatty pancreatic disease and cardio-metabolic risk: is there is a place for obstructive sleep apnea? Cardiovasc Diabetol 2014; 13: 29. Dostupné z DOI: <http://dx.doi.org/10.1186/1475–2840–13–29>.
- Bojková M, Dítě P. Obezita ve vztahu k onemocnění pankreatu. Interní Med 2016; 18(4): 176–178.
- Acharya Ch, Navina S, Singh VP. Role of pancreatic fat in the outcomes of pancreatitis. Pancreatology 2014; 14(5): 403–408. Dostupné z DOI: <http://dx.doi.org/10.1016/j.pan.2014.06.004>.
- Vašura A, Blaho M, Dítě P et al. Adiponektin u nemocných s metabolickým syndromem a chorobami jater, žlučových cest a pankreatu. Vnitř Lék 2017; 63(12): 945–948.
- Ou HY, Wang CY, Yang Y Cet al. The association between nonalcoholic fatty pancreas disease and diabetes. PloS One 2013; 8(5): e62561. Dostupné z DOI: <http://dx.doi.org/10.1371/journal.pone.0062561>.
- Yu TY, Wang CY. Impact of non‐alcoholic fatty pancreas disease on glucose metabolism. J Diabetes Investig 2017; 8(6): 735–747. Dostupné z DOI: <http://dx.doi.org/10.1111/jdi.12665>.
- Tushuizen ME, Bunck MC, Pouwels PJ et al. Pancreatic fat content and β-cell function in men with and without type 2 diabetes. Diabetes Care 2007; 30(11): 2916–2921. Dostupné z DOI: <http://dx.doi.org/10.2337/dc07–0326>. Erratum in Diabetes Care 2008; 31(4): 835.
- van der Zijl NJ, Goossens GH, Moors CC et al. Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab 2011; 96(2) :459–467. Dostupné z DOI: <http://dx.doi.org/10.1210/jc.2010–1722>.
- Tomita Y, Azuma K, Nonaka Y et al. Pancreatic fatty degeneration and fibrosis as predisposing factors for the development of pancreatic ductal adenocarcinoma. Pancreas 2014; 43(7): 1032–1041. Dostupné z DOI: <http://dx.doi.org/10.1097/MPA.0000000000000159>.
- Lesmana CRA, Gani RA, Lesmana LA. Non‐alcoholic fatty pancreas disease as a risk factor for pancreatic cancer based on endoscopic ultrasound examination among pancreatic cancer patients: A single‐center experience. JGH Open 2018; 2(1): 4–7. Dostupné z DOI: <https://doi.org/10.1002/jgh3.12032>.
- Tranchart H et al. Preoperative CT scan helps to predict the occurrence of severe pancreatic fistula after pancreaticoduodenectomy. Ann Surg 2012; 256(1): 139–145. Dostupné z DOI: <http://dx.doi.org/10.1097/SLA.0b013e318256c32c>.
- Gaujoux S et al. Impact of obesity and body fat distribution on survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Ann Surg Oncol 2012; 19(9): 2908–2916. Dostupné z DOI: <http://dx.doi.org/10.1245/s10434–012–2301-y>.
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
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