Is glucosis only basic energy substrate?

Czech version

Authors: Luboš Sobotka
Authors‘ workplace: III. interní gerontolometabolická klinika LF UK a FN Hradec Králové
Published in: Vnitř Lék 2016; 62(Suppl 4): 100-102
Category: Reviews

Overview

At present time glucose is primarily considered as basic energy substrate. Therefore, it is recommended to give amount of glucose which is necessary for oxidation and energy production. As critical illness is connected with so-called insulin resistance, it is recommended to reduce the glucose dose and maintain normal blood glucose. Glucose, however, may not only be the principal energy substrate but also the substrate necessary for many metabolic reactions, which are essential for normal reactivity and survival.

Key words:
energy – glucose – glucose requirement – glucose turnover

Sources

1. Singer P, Berger MM, Van den Berghe G et al. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr 2009; 28(4): 387–400. Dostupné z DOI: <http://dx.doi.org/10.1016/j.clnu.2009.04.02>.

2. Van den Berghe G, Wouters P, Weekers F et al. Intensive insulin therapy in the critically ill patients. N Eng J Med 2001; 345(19): 1359–1367.

3. Van den Berghe G, Wilmer A, Hermans G et al. Intensive insulin therapy in the medical ICU. New Engl J Med 2006; 354(5): 449–461.

4. Finfer S, Heritier S. [NICE Study Management Committee and SUGAR Study Executive Committee]. The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan. Crit Care Resusc 2009; 11(1): 46–57.

5. Preiser JC, Devos P, Ruiz-Santana S et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med 2009; 35(10): 1738–1748.

6. Rusavy Z, Sramek V, Lacigova S et al. Influence of insulin on glucose metabolism and energy expenditure in septic patients. Crit Care 2004; 8(4): R213-R220.

7. Rusavy Z, Macdonald IA, Sramek V et al. Glycemia influences on glucose metabolism in sepsis during hyperinsulinemic clamp. JPEN J Parenter Enteral Nutr 2005; 29(3): 171–175.

8. Champagne CD, Houser DS, Crocker DE. Glucose production and substrate cycle activity in a fasting adapted animal, the northern elephant seal. J Exp Biol 2005; 208(pt 5): 859–868.

9. Soeters MR, Soeters PB. The evolutionary benefit of insulin resistance. Clin Nutr 2012; 31(6): 1002–1007.

10. Agwunobi AO, Reid C, Maycock P et al. Insulin resistance and substrate utilization in human endotoxemia. J Clin Endocrinol Metab 2000; 85(10): 3770–3778.

11. Brealey D, Singer M. Hyperglycemia in critical illness: a review. J Diabetes Sci Technol 2009; 3(6): 1250–1260.

12. Ralser M, Wamelink MM, Kowald A et al. Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress. J Biol 2007; 6(4): 10.