Application of stem cells in orthopedics
Authors:
Pavel Žák
Authors‘ workplace:
IV. interní hematologická klinika LF UK a FN Hradec Králové, přednosta doc. MUDr. Pavel Žák, Ph. D.
Published in:
Vnitř Lék 2015; 61(6): 597-598
Category:
Předneseno na mezioborovém sympoziu s postgraduálním zaměřením „Diabetik – společný pacient diabetologa a ortopeda“ 10. října 2014 v Hradci Králové.
Overview
Regeneration of articular cartilage remains a major challenge in orthopaedics. Cell-based therapies (with chondrocyte and MSCs – mesenchymal stem cells) to augment cartilage repair have received considerable interest during recent years. Adipose MSCs have been used in the Czech Republic for osteoarthritis therapy, despite not being recommended by the Czech Orthopaedic Association. This lecture reviews the studies and their level of evidence for orthopaedic routine therapy of osteoarthritis.
Key words:
mesenchymal stem cells – osteoarthritis
Sources
1. Izadpanath R, Kaushal D, Kriedt C et al. Long-term in vitro expansion alter the biology of adult mesenchymal stem cells. Cancer Res 2008; 68(11): 4229–4238.
2. Centeno CJ, Busse D, Kisiday J et al. Increased knee cartilage volume in degenerative joint disease usány percutaneously implanted autologous mesenchymal stem cells. Pain Physician 2008; 11(3): 343–353.
3. Centeno CJ, Kisiday J, Freeman M et al. Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer. Pain Physician 2006; 9(3): 253–256.
4. Vangsness CT, Farr J, Boyd J et al. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial menisectomy. J Bone Point Surg Am 2014; 96(2): 90–98.
5. Peeters CM, Leijs MJ, Reijman M et al. Safety of intra-articular cell-therapy with culture -expanded stem cells in humans: A systematic literature review. Osteoarthritis Cartilage 2013; 21(10): 1465–1473.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2015 Issue 6
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