Lipids and the size of lipoprotein particles in newly diagnosed and untreated patients with type 2 diabetes mellitus

Czech version

Authors: A. Dukát ¹; Ľ. Fábryová ²; S. Oravec ¹; P. Sabaka ¹; L. Mistríková ³; D. Baláž ¹; P. Gavornik ¹; Ľ. Gašpar ¹
Authors‘ workplace: II. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednosta doc. MU Dr. Ľudovít Gašpar, CSc. 2 Diabetologická ambulancia, ambulancia pre metabolické choroby a poruchy výživy Metabol Klinik Bratislava, Slovenská republika, vedú ¹; Kardiochirurgická klinika Východoslovenského ústavu srdcových a cievnych chorôb Košice, Slovenská republika, prednostka prof. MU Dr. Mária Frankovičová, PhD. ³
Published in: Vnitř Lék 2013; 59(6): 450-452
Category: 80th birthday prof. MUDr. Karla Horkého, DrSc., FACP (Hon.)

Overview

Type 2 diabetes mellitus leads to the typical known form of dyslipidaemia among the patients. This dyslipiademia type represents prognostically important type of atherogenic dyslipiadaemia, that significatly increases the risk of atherothrombosis. Estimation of the size of lipoprotein particles with Lipoprint method among newly diagnosed, untreated patients with these patients have not been evaluated yet. Dyslipidaemia among patients with type 2 diabetes mellitus has its course and changes after the treatment. At the beginning i tis characterized by the significant increase of VLDL, large and middle size IDL lipoprotein particles, as well as by lowering of HDL particles. This lipoprotein profile has its own atherogenic potential. The course of the disease later leads to the change of dyslipidaemia, characterized by the increase of LDL levels (small dense particles), triglyceride levels and the persistence of the lower levels of HDL‑cholesterol. Hypolipidemic treatment leads to the significant lowering of cardiovascular risk, however despite treatment with statin or fibrate residual cardiovascular risk remains still very high.

Key words:
diabetes mellitus – dyslipoproteinaemias – residual cardiovascular risk

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