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Targeted therapeuticts and their role in the treatment of internal diseases


Authors: P. Klener
Authors‘ workplace: I. interní klinika 1. lékařské fakulty UK a VFN a ÚHKT Praha, přednosta prof. MUDr. Marek Trněný, CSc.
Published in: Vnitř Lék 2013; 59(1): 5-12
Category: Celebratory Discourse

Předneseno jako slavnostní přednáška na zahájení XIX. kongresu České internistické společnosti České lékařské společnosti J. E. Purkyně v Brně dne 24. října 2012.

Overview

Targeted therapy is a conceptual notion that should be used for such a treatment approach that has been developed based upon the known pathophysiology and/or biomarkers of a particular disease, mainly malignancies. Monoclonal antibodies and tyrosine--kinase inhibitors were among the first molecularly targeted agents. Monoclonal antibodies approach is based on targeting a biomarker expressed either on the surface of cancer cells or targeting different cytokines. Tyrosin-kinase inhibitors are directed at the druggable molecule involved in the cancer pathophysiology inhibiting aberrant tyrosin-kinase activity. Classification of targeted drugs and their use in the clinical practice is shortly reviewed.

Key words:
targeted therapy – monoclonal antibodies – tyrosin-kinase inhibitors – classification – clinical use


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