#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Natural substances affecting type 2 diabetes


Authors: L. Jahodář
Authors‘ workplace: Katedra farmaceutické botaniky a ekologie Farmaceutické fakulty UK Hradec Králové, přednosta prof. RNDr. Luděk Jahodář, Ph. D.
Published in: Vnitř Lék 2009; 55(4): 416-420
Category:

Overview

More than 1,000 species of seed plants and fungi are active in hypoglycemic tests. The potential of their effective molecules is considerable; it could be also expected, that the mechanism of their activity will be very varied. Even though the majority of information is only screening of hypoglycemic effect, there occur the results of valid essays, which report on the possible mechanisms of the activity. This paper represents the attempt at the categorisation of plant drugs, their fractions and isolated substances according to their pharmacological activity and mechanism of the effect.

Key words:
plant hypoglycemics – plant metabolites and DM type 2 – categorization of antidiabetic activity


Sources

1. Sarkar S, Pranava M, Marita R. Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes. Pharmacol Res 1996; 33: 1–4.

2. Jahodář L. Antidiabetika rostlinného původu. Českoslov Farm 1993; 42: 251–259.

3. Suchý V, Žemlička M, Švajdlenka E et al. Léčivé rostliny a diabetes mellitus. Čes slov Farm 2008; 57: 78–84.

4. Mohamed B, Abderrahim Z, Hassane M et al. Medicinal plants with potential antidiabetic activity – A review of ten years of herbal medicine research (1990–2000). Int J Diabetes Metab 2006; 14: 1–25.

5. Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989; 12: 553–564.

6. Kozak JA, Misler S, Logothetis DE. Characterization of a Ca2+ acitvated K+ current in insulin‑secreting murine beta TC–3 cells. J Physiol 1998; 509: 355–370.

7. Dyer JR, Davis TM, Giele C et al. The pharmacokinetics and pharmacodynamics of quinine in the diabetic and non‑diabetic elderly. Br J Clin Pharmacol 1994; 38: 205–212.

8. Komatsu M, Sato Y, Yamada S et al. Triggering of insulin release by a combination cAMP signal and nutrients: an ATP-sensitive K+ channel-dependent phenomenon. Diabetes 2002; 51 (Suppl 1): S29–S32.

9. Hill RS, Oberwetter JM, Boyd AE 3rd. Increase in cAMP levels in beta‑cell line potentiates insulin secretion without altering cytosolic free-calcium concentration. Diabetes 1987; 36: 440–446.

10. Hii CS, Howell SL. Effects of epicatechin on rat islets of Langerhans. Diabetes 1984; 33: 291–296.

11. Ivorra MD, Paya M, Villar A. Hypoglycemic and insulin release effects of tormentic acid: a new hypoglycemic natural product. Planta Med 1988; 54: 282–285.

12. Yutaka S, Hiroshi H. Mechanisms of hypoglycemic activity of panaxans A and B, glycans of Panax ginseng roots: Effects on the key enzymes of glucose metabolism in the liver of mice. Phytoth Res 1989; 3: 15–19.

13. Keane D, Newsholme P. Saturated and unsaturated (including arachidonic acid) non esterified fatty acid modulation of insulin secretion from pancreatic beta‑cells. Biochem Soc Trans 2008; 36: 955–958.

14. Maroo J, Vasu VT, Aalinkeel R et al. Glucose lowering effect of aqueous extract of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action. J Ethnopharmacol 2002; 81: 317–320.

15. Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food 2008; 11: 152–159.

16. Beppu H, Shimpo K, Chihara T. Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low‑dose streptozotocin‑induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. J Ethnopharmacol 2006; 103: 468–477.

17. Khanna P, Jain SC, Panagariya A et al. Hypoglycemic activity of polypeptide-p from a plant named Momordica chirantia. J Nat Prod 1981; 44: 648–655.

18. Kim YM, Kim SG, Khil LY et al. Brazilin stimulates the glucose transport in 3T3-L1 cells. Planta Med 1995; 61: 297–301.

19. Sheela CG, Kumud K, Augusti KT. Anti‑diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 1995; 61: 356–357.

20. Augusti KT, Sheela CG. Antiperoxide effect of S-allyl cysteine sulfoxide, a insulin secretagogue, in diabetic rats. Experientia 1996; 52: 115–120.

21. Jahodár L, Opletal L, Lukes J et al. A study on the antihypercholesterolemic and antihyperlipidemic effects of cabbage extracts and their phytochemical evaluation. Pharmazie 1995; 50: 833–834.

22. Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomed 1995; 2: 137–189.

23. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990; 44: 301–306.

24. Seltzer HS. Quantitative effects of glucose, sulfonylureas, salicylate, and indole-3-acetic acid on the secretion of insulin activity into pancreatic venous blood. J Clin Invest 1962; 41: 289–300.

25. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamom functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001; 20: 327–336.

26. Khan A, Safdar M, Ali Khan MM et al. Cinnamom improves glucose and lipid of people with type 2 diabetes. Diabetes Care 2003; 26: 3215–3218.

27. Svoboda GH, Gorman M, Root MA. Alkaloids of Vinca rosea (Catharanthus roseus). A preliminary report on hypoglycemic activity. Lloydia 1964; 27: 361–363.

28. Kuriyan R, Rajendran R, Bantwal G et al. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008; 31: 216–220.

29. Rao VV, Kwivedi SK, Swarup D. Hypoglycemic effect of Musa sapientum unripe fruits in rabbits. Fitoterapia 1994; 65: 65–67.

30. Lintas C, Cappelloni M, Adorisio S et al. Effect of ripening on resistant starch and total sugars in Musa paradisiaca sapientum glycemic an insulinaemic responses in normal subjects and NIDDM patients. Eur J Clin Nutr 1995; 49 (Suppl 3): S303–S306.

31. Nishimura H, Morota T, Yamaguchi, T et al. Extraction of phenethyl alcohol derivatives as aldose reductase inhibitors for treatment of diabetes‑related diseases. Japan Kokai Tokkyo Koho (Patent): 13. Patent number: JP 02036189, 1990.

32. Takanashi M, Konno C, Hikino H. Isolation and hypoglycemic activity of anemarans A,B,C and D glycans of Anemarrhena asphodeloides rhizomes. Planta Med 1985; 51: 100–102.

33. Li WL, Zheng HC, Bukuru J et al. Natural medicines used in traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004; 92: 1–21.

34. Sherratt HA. Hypoglycin, the famous toxin of the unripe. Jamaican ackee fruit. Trends Pharmacol Sci 1986; 7: 186–191.

35. Voet D, Voetová JG. Biochemie. Praha: Victoria Publushing 1995; 699–701.

36. Turner CE, Craig JC Jr. United States Patent 3,950,518 Apr. 13, 1976.

37. Klingenberg M. The ADP and ATP transport in mitochondria and its carrier. Biochim Biophys Acta 2008; 1778: 1978–2021.

38. Owen MR, Halestrap AP. The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis. Biochim Biophys Acta 1993; 1142: 11–22.

39. Liou SS, Liu IM, Lai MC. The plasma glucose lowering action of Hei-Shug-Pian, the fire‑processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin‑induced diabetic rats. J Ethnopharmacol 2006; 106: 256–262.

40. Boh B, Berovic M, Zhang J et al. Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev 2007; 13: 265–301.

41. Sánchez de Medina F, Gámez MI, Jiménez I et al. Hypoglycemic activity of juniper „berries“. Planta Med 1994; 60: 197–200.

42. Kim JH, Ryu YB, Kang NS et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull 2006; 29: 302–305.

43. Sierra M, García JJ, Fernández N et al. Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr 2002; 56: 830–842.

44. Prieto PG, Cancelas J, Villanueva-Penacarrillo ML et al. Short‑term and long‑term effects of guar on postprandial plasma glucose, insulin and glucagon‑like peptide 1 concentration in healthy rats. Horm Metab Res 2006; 38: 397–404.

45. Mukhtar HM, Ansari SH, Ali M et al. Effect of aqueous extract of Cyamopsis tetragonoloba Linn. beans on blood glucose level in normal and alloxan‑induced diabetic rats. Indian J Exp Biol 2004; 42: 1212–1215.

46. Jain SC, Lohiya NK, Kapoor A. Trigonela foenum-graecum Linn.: a hypoglycaemic agent. Indian J Pharm Sci 1987; 49: 113–114.

47. Makoto S, Yoko K, Miho S et al. Regulation of intestinal glucose transport by tea catechins. BioFactors 2008; 13: 61–65.

48. Yoshikuni Y, Ezure Y, Aoyagi Y et al. Inhibition of intestinal alpha-glucosidase activity and postprandial hyperglycemia by N-substituted moranoline derivatives. J Pharmacobiodyn 1988; 11: 356–362.

49. Winchester BG, Cenci di Bello I, Richardson AC. The structural basis of the inhibition of human glycosidases by castanospermine analogues. Biochem J 1990; 269: 227–231.

50. Willenborg DO, Parish CR, Cowden WB. Inhibition of adjuvant arthritis in the rat by phosphosugars and the -glucosidase inhibitor castanospermine. Immunol Cell Biol 1992; 70: 369–377.

51. Chattopadhyay RR. Possible mechanism of antihyperglycemic of Gymnema sylvestre leaf extract, part 1.Gen Pharmacol 1998; 31: 495–496.

52. Rau O, Wurglics M, Dingermann T et al. Screening of herbal extracts for activation of the human peroxisome proliferator‑activated receptor. Pharmazie 2006; 61: 952–956.

53. Rau O, Wurglics M, Paulke A et al. Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator‑activated receptor gamma. Planta Med 2006; 72: 881–887.

54. Kimura Y, Okuda H, Arichi S. Effects of the extracts of Ganoderma lucidum on blood glucose level in rats. Planta Med 1988; 54: 290–294.

55. Leng Y, Steiler TL, Zierath JR. Effects of insulin, contraction, and phorbol esters on mitogen‑activated protein kinase signaling in skeletal muscle from lean and ob/ob mice. Diabetes 2004; 53: 1436–1444.

56. Abdel-Zaher AO, Ahmed IT, El-Koussi AD. The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. Pharmacol Res 2001; 44: 397–409.

57. Choi SY, Jung SH, Lee HS et al. Glycation Inhibitory activity and the odentification of an active compound in Plantago asiatica extract. Phytother Res 2008; 22: 323–329.

58. Jang DS, Yoo NH, Lee YM et al. Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase. Arch Pharm Res 2008; 31: 900–904.

59. Seo KI, Choi MS, Jung UJ et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res 2008; 52: 995–1004.

60. Felício JD, Gonçalez E, Braggio MM et al. Inhibition of lens aldose reductase by biflavones from Ouratea spectabilis. Planta Med 1995; 61: 217–220.

61. Jung HA, Yoon NY, Bae HJ et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res 2008; 31: 1405–1412.

62. Jang DS, Lee GY, Kim YS et al. Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Biol Pharm Bull 2007; 30: 2207–2210.

63. Lim SS, Jung YJ, Hyun SK et al. Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens. Phytother Res 2006; 20: 825–830.

64. Matsuda H, Nishida N, Yoshikawa M. Antidiabetic principles of natural medicines. V. Aldose reductase inhibitors from Myrcia multiflora DC. (2): Structures of myrciacitrins III, IV, and V. Chem Pharm Bull (Tokyo) 2002; 50: 429–431.

65. Lee SH, Shim SH, Kim JS et al. Constituents from the fruiting bodies of Ganoderma applanatum and theirt aldose reductase inhibitory activity. Arch Pharm Res 2006; 29: 479–483.

66. Archimovicz-Cyrylowska B, Adamek B, Drozdzik M. Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. Phytother Res 1996; 10: 659–662.

67. Aguilar Peralta GR, Arévalo Gardoqui J, Liamas Macias FJ et al. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol 2007; 26: 378–384.

68. Kanamaru T, Shinagawa S, Asai M et al. Emeriamine, an antidiabetic beta‑aminobetain derived from a novel fungal metabolite. Life Sci 1985; 37: 217–223.

69. Eddouks M, Maghrani M. Effect of Lepidium sativum L. on renal glucose reabsorption and urinary TGF‑beta1 levels in diabetic rats. Phytother Res 2008; 22: 1–5.

70. Castaneda F, Burse S, Boland W et al. Thioglycosides as inhibitors of hSGLT 1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes. In J Med Sci 2007; 4: 131–139.

71. Sato S, Takeo J, Aoyama C et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem 2007; 15: 3445–3449.

72. Idris I, Donnelly R. Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug. Diabetes Obes Metab 2009; 11: 79–88.

73. Xue M, Qian Q, Adaikalakoteswari Aet al. Activation of NF-E2-Related Fac­tor–2 Reverse Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease. Diabetes 2008; 57: 2809–2817.

74. Helmstädter A. Antidiabetic drugs used in Europe prior to the discovery of insulin. Pharmazie 2007; 62: 717–720.

Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue 4

2009 Issue 4

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#