PCSK9 inhibitors and the role of evolocumab in the therapy for patients with hyperlipoproteinemia
Authors:
Andrej Dukát 1; Milan Kriška 2; P. Sabaka 3; P. Gavornik 4; M. Kužma 1; Juraj Payer 1
Authors‘ workplace:
V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
1; Ústav farmakológie a klinickej farmakológie LF UK v Bratislave
2; Klinika infektológie a geografickej medicíny LF UK, SZU a UNB, Nemocnica akad. L. Dérera, Bratislava
3; Angiologická sekcia SLK, Bratislava
4
Published in:
Forum Diab 2018; 7(1): 71-75
Category:
Overview
Relationship between LDL-cholesterol levels and cardiovascular risk is clear nowadays in the evidence-based medicine. Similarly also in the place of statins as the first line therapy among high cardiovascular risk patients. Despite significant improvements in the dyslipidemia therapy for the secondary prevention with statins, this mode of therapy has still certain limitations. Limitations of hypolipidemic treatment have at present two sorts of problems: first is patient and second is the therapy. Therefore new possibilities for significant influence on LDL-cholesterol levels are in research. Nowadays the important place represents the biologic treatment with PCSK-9 inhibitors.
Key words:
atherothrombosis, dyslipidemias, LDL-cholesterol, PCSK9 inhibitors, therapy
Received:
13. 12. 2017
Accepted:
25. 1. 2018
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Diabetology Endocrinology Internal medicineArticle was published in
Forum Diabetologicum
2018 Issue 1
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